Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
TI Food and Nutrition, Wageningen, The Netherlands.
Nat Commun. 2021 Aug 6;12(1):4773. doi: 10.1038/s41467-021-24956-2.
The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology and function remain unclear. In the current study, we examined to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging and compared mitochondrial function in young and older adults, with similar habitual physical activity levels. We also studied exercise-trained older adults and physically impaired older adults. Aging was associated with a decline in mitochondrial capacity, exercise capacity and efficiency, gait stability, muscle function, and insulin sensitivity, even when maintaining an adequate daily physical activity level. Our data also suggest that a further increase in physical activity level, achieved through regular exercise training, can largely negate the effects of aging. Finally, mitochondrial capacity correlated with exercise efficiency and insulin sensitivity. Together, our data support a link between mitochondrial function and age-associated deterioration of skeletal muscle.
线粒体功能随年龄相关衰退及其对骨骼肌生理学和功能的影响尚不清楚。在本研究中，我们探究了在衰老过程中，体力活动在多大程度上导致线粒体功能和肌肉健康下降，并比较了具有相似习惯性体力活动水平的年轻和老年成年人的线粒体功能。我们还研究了经过锻炼的老年成年人和身体受损的老年成年人。即使保持足够的日常体力活动水平，衰老也与线粒体容量、运动能力和效率、步态稳定性、肌肉功能和胰岛素敏感性的下降有关。我们的数据还表明，通过定期运动训练进一步提高体力活动水平，可以在很大程度上消除衰老的影响。最后，线粒体容量与运动效率和胰岛素敏感性相关。总之，我们的数据支持线粒体功能与骨骼肌衰老相关恶化之间的联系。
