Holmberg S B, Hafström L, Kjellberg G
Department of Surgery 1, Sahlgrenska Hospital, Göteborg, Sweden.
Eur J Cancer Clin Oncol. 1987 Dec;23(12):1883-7. doi: 10.1016/0277-5379(87)90054-x.
This experimental study in rats examines tumour take and growth after RES modulation in an organ rich in macrophages--the liver--vs. an organ poor in macrophages--the kidney. A control group of 16 rats had 1.0 X 10(6) transplantable adenocarcinoma cells inoculated in the liver and the same number in the left kidney. They were compared with a RE-stimulated group of 16 rats treated i.v. with Zymosan (3 mg/100 g for 3 days) and a RE-depressed group of 16 rats treated with i.v. methylpalmitate (100 mg/100 g for 3 days) before tumour inoculation. Tumour size was measured on days 7 and 14. The animals were killed on day 14. Mortality was significantly higher in methylpalmitate-treated rats than in control groups. Tumour take in the kidney was not affected by RES stimulation or depression. In the liver, RES stimulation caused significantly less tumour take. Depression of RES with methylpalmitate did not increase tumour take or tumour growth in the liver, which was very high in the control group.
这项针对大鼠的实验研究，考察了富含巨噬细胞的器官（肝脏）与巨噬细胞较少的器官（肾脏）在RES调节后肿瘤的接种和生长情况。16只大鼠组成的对照组在肝脏接种1.0×10(6)个可移植腺癌细胞，在左肾接种相同数量的细胞。将它们与16只经静脉注射酵母聚糖（3毫克/100克，共3天）处理的RES刺激组大鼠，以及16只在接种肿瘤前经静脉注射甲基棕榈酸酯（100毫克/100克，共3天）处理的RES抑制组大鼠进行比较。在第7天和第14天测量肿瘤大小。在第14天处死动物。甲基棕榈酸酯处理的大鼠死亡率显著高于对照组。肾脏中的肿瘤接种不受RES刺激或抑制的影响。在肝脏中，RES刺激导致肿瘤接种显著减少。用甲基棕榈酸酯抑制RES并没有增加肝脏中的肿瘤接种或肿瘤生长，对照组肝脏中的肿瘤接种和生长非常高。
