Rydén S, Bergqvist L, Hafström L, Hultberg B, Stenram U, Strand S E
J Surg Oncol. 1984 Aug;26(4):245-51. doi: 10.1002/jso.2930260409.
Reticuloendothelial (RE) function was evaluated by measuring the biokinetics of a standardized 99Tcm-sulphur colloid. Methyl palmitate was administered intravenously on two consecutive days. A statistically significant reduction in the colloid uptake rate of the liver was registered after methyl palmitate administration. Histological examination revealed no signs of destruction of RE cells or microembolization. Inoculation of an experimental nitrosoguanidine-induced transplantable adenocarcinoma to the liver was performed in 16 rats one day after methyl palmitate administration and in 16 controls. Tumor size was significantly larger in methyl-palmitate-treated animals at 7 and 14 days after inoculation. Survival was significantly decreased in methyl-palmitate-treated rats. These rats showed signs of fatty vacuolization and necrosis of liver parenchyma earlier than controls. Analyses of beta-hexosaminidase and lactate dehydrogenase revealed no deviation of enzyme levels either before or after tumor inoculation. The results indicate that a temporary suppression of RE function at the time of tumor inoculation may influence subsequent tumor growth.
通过测量标准化的99锝-硫胶体的生物动力学来评估网状内皮（RE）功能。连续两天静脉注射棕榈酸甲酯。注射棕榈酸甲酯后，肝脏胶体摄取率出现统计学上的显著降低。组织学检查未发现RE细胞破坏或微栓塞的迹象。在注射棕榈酸甲酯一天后，对16只大鼠进行实验性亚硝基胍诱导的可移植性肝癌接种，并设16只对照。接种后7天和14天，棕榈酸甲酯处理组动物的肿瘤体积明显更大。棕榈酸甲酯处理的大鼠存活率显著降低。这些大鼠比对照组更早出现肝实质脂肪空泡化和坏死的迹象。对β-己糖胺酶和乳酸脱氢酶的分析表明，肿瘤接种前后酶水平均无偏差。结果表明，肿瘤接种时RE功能的暂时抑制可能会影响后续肿瘤的生长。
