Institute of Science and Technology, Laboratory of Electrochemistry and Applied Nanotechnology, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Brazil.
Department of Natural Sciences, Federal University of São João Del-Rei, São João Del-Rei, Brazil.
Talanta. 2021 Nov 1;234:122617. doi: 10.1016/j.talanta.2021.122617. Epub 2021 Jun 15.
A group of infectious and parasitic diseases with prevalence in tropical and subtropical regions of the planet, especially in places with difficult access, internal conflicts, poverty, and low visibility from the government and health agencies are classified as neglected tropical diseases. While some well-intentioned isolated groups are making the difference on a global scale, the number of new cases and deaths is still alarming. The development and employment of low-cost, miniaturized, and easy-to-use devices as biosensors could be the key to fast diagnosis in such areas leading to a better treatment to further eradication of such diseases. Therefore, this review contains useful information regarding the development of such devices in the past ten years (2010-2020). Guided by the updated list from the World Health Organization, the work evaluated the new trends in the biosensor field applied to the early detection of neglected tropical diseases, the efficiencies of the devices compared to the traditional techniques, and the applicability on-site for local distribution. So, we focus on Malaria, Chagas, Leishmaniasis, Dengue, Zika, Chikungunya, Schistosomiasis, Leprosy, Human African trypanosomiasis (sleeping sickness), Lymphatic filariasis, and Rabies. Few papers were found concerning such diseases and there is no available commercial device in the market. The works contain information regarding the development of point-of-care devices, but there are only at proof of concepts stage so far. Details of electrode modification and construction of electrochemical biosensors were summarized in Tables. The demand for the eradication of neglected tropical diseases is increasing. The use of biosensors is pivotal for the cause, but appliable devices are scarce. The information present in this review can be useful for further development of biosensors in the hope of helping the world combat these deadly diseases.
一组在地球的热带和亚热带地区流行的传染病和寄生虫病，特别是在难以进入、存在内部冲突、贫困和政府及卫生机构关注度低的地方，被归类为被忽视的热带病。虽然一些善意的孤立团体在全球范围内产生了影响，但新发病例和死亡人数仍然令人震惊。开发和使用低成本、微型化、易于使用的设备作为生物传感器，可能是在这些地区快速诊断的关键，从而改善治疗效果，进一步消除这些疾病。因此，本综述包含了过去十年（2010-2020 年）开发此类设备的有用信息。根据世界卫生组织更新的清单，该工作评估了应用于被忽视热带病早期检测的生物传感器领域的新趋势，与传统技术相比设备的效率，以及现场应用的适用性，用于当地分发。因此，我们专注于疟疾、恰加斯病、利什曼病、登革热、寨卡病毒、基孔肯雅热、血吸虫病、麻风病、人类非洲锥虫病（昏睡病）、淋巴丝虫病和狂犬病。关于这些疾病的论文很少，市场上也没有现成的商业设备。这些工作包含了关于即时检测设备的开发信息，但迄今为止，这些设备仅处于概念验证阶段。电化学生物传感器的电极修饰和构建的详细信息总结在表格中。消除被忽视的热带病的需求正在增加。生物传感器的使用对该事业至关重要，但适用的设备却很少。本综述中提供的信息对于进一步开发生物传感器可能会很有用，希望能够帮助世界对抗这些致命疾病。
