Dudzińska Ewa, Szymona Kinga, Bogucki Jacek, Koch Wojciech, Cholewińska Ewelina, Sitarz Robert, Ognik Katarzyna
Department of Food and Nutrition, Medical University of Lublin, 20-093 Lublin, Poland.
Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland.
J Clin Med. 2022 May 2;11(9):2551. doi: 10.3390/jcm11092551.
Schizophrenia is a severe and chronic mental illness usually diagnosed in adolescents and young adults. Many studies indicate that oxidative stress causes membrane dysfunction and cell damage, which is implicated in the pathophysiology of schizophrenia. The purpose of our study was to evaluate oxidative stress markers (the main primary products of lipid peroxidation, lipid hydroperoxides (LOOH), and end products of lipid peroxidation, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and Ferric Reducing Ability of Plasma (FRAP)) in the plasma of patients with the first episode of schizophrenia in drug-naïve patients (22 men and 12 women aged 17-29). The control group (Ctrl) comprised 26 healthy subjects (19 men and 7 women, aged 18-30 years). The Positive and Negative Syndrome Scale (PANSS) was applied to evaluate psychotic symptoms. Analyses of the oxidative stress variables revealed an increased level of SOD (U/mL) in subjects with schizophrenia versus control group. In addition, lipid damage measured as LOOHs µ (mol/L) and MDA was significantly higher in patients with schizophrenia in comparison to control subjects. There was a positive correlation between MDA µmol/L and PANSS P and a positive correlation between C-reactive protein (CRP) and the PANSS P scale. The elevated level of superoxide dismutase in patients with the first episode of schizophrenia can be explained by compensatory mechanisms to counteract oxidative stress. Malondialdehyde can be used as a simple biomarker of low-grade systemic inflammation associated with oxidative stress. A positive correlation between CRP and PANSS P scale and MDA and PANSS P scale may indicate a significant relationship between the development of low-grade inflammation and damage associated with oxidative stress in the development of the first symptoms of schizophrenia.
精神分裂症是一种严重的慢性精神疾病，通常在青少年和青年时期被诊断出来。许多研究表明，氧化应激会导致膜功能障碍和细胞损伤，这与精神分裂症的病理生理学有关。我们研究的目的是评估首次发作且未使用过药物的精神分裂症患者（22名男性和12名女性，年龄在17至29岁之间）血浆中的氧化应激标志物（脂质过氧化的主要初级产物、脂质氢过氧化物（LOOH）以及脂质过氧化的终产物丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）和血浆铁还原能力（FRAP））。对照组（Ctrl）由26名健康受试者组成（19名男性和7名女性，年龄在18至30岁之间）。使用阳性和阴性症状量表（PANSS）来评估精神症状。对氧化应激变量的分析显示，与对照组相比，精神分裂症患者的SOD（U/mL）水平升高。此外，以LOOHs μ（mol/L）和MDA衡量的脂质损伤在精神分裂症患者中显著高于对照受试者。MDA μmol/L与PANSS P之间存在正相关，C反应蛋白（CRP）与PANSS P量表之间也存在正相关。首次发作的精神分裂症患者超氧化物歧化酶水平升高可以通过对抗氧化应激的补偿机制来解释。丙二醛可作为与氧化应激相关的低度全身炎症的简单生物标志物。CRP与PANSS P量表以及MDA与PANSS P量表之间的正相关可能表明在精神分裂症首发症状的发展过程中，低度炎症的发展与氧化应激相关损伤之间存在显著关系。
