Du Yuxiang, Wang Zhikun, Wu Yangming, Liu Chengyi, Zhang Lingli
School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
School of Physical Education & Sports Science, South China Normal University, Guangzhou, 510631 Guangdong, China.
Stem Cells Int. 2021 Jul 28;2021:2130727. doi: 10.1155/2021/2130727. eCollection 2021.
Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back pain (LBP), which has become more prevalent from 21 century, causing an enormous economic burden for society. However, in spite of remarkable improvements in the basic research of IVD degeneration (IVDD), the effects of clinical treatments of IVDD are still leaving much to be desired. Accumulating evidence has proposed the existence of endogenous stem/progenitor cells in the IVD that possess the ability of proliferation and differentiation. However, few studies have reported the biological properties and potential application of IVD progenitor cells in detail. Even so, these stem/progenitor cells have been consumed as a promising cell source for the regeneration of damaged IVD. In this review, we will first introduce IVD, describe its physiology and stem/progenitor cell niche, and characterize IVDSPCs between homeostasis and IVD degeneration. We will then summarize recent studies on endogenous IVDSPC-based IVD regeneration and exogenous cell-based therapy for IVDD. Finally, we will discuss the potential applications and future developments of IVDSPC-based repair of IVD degeneration.
椎间盘退变被认为是腰痛的主要原因，自21世纪以来，腰痛变得更加普遍，给社会带来了巨大的经济负担。然而，尽管椎间盘退变的基础研究取得了显著进展，但椎间盘退变的临床治疗效果仍不尽人意。越来越多的证据表明，椎间盘中存在具有增殖和分化能力的内源性干/祖细胞。然而，很少有研究详细报道椎间盘祖细胞的生物学特性和潜在应用。即便如此，这些干/祖细胞已被视为受损椎间盘再生的有前景的细胞来源。在本综述中，我们将首先介绍椎间盘，描述其生理学和干/祖细胞微环境，并表征稳态与椎间盘退变之间的椎间盘干细胞/祖细胞。然后，我们将总结基于内源性椎间盘干细胞/祖细胞的椎间盘再生和基于外源性细胞的椎间盘退变治疗的最新研究。最后，我们将讨论基于椎间盘干细胞/祖细胞修复椎间盘退变的潜在应用和未来发展。
