Jia Zhiwei, Liu Donghua, Li Xingxuan, Wen Tianlin, Li Wei
Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing, People's Republic of China.
J Inflamm Res. 2023 Dec 4;16:5791-5806. doi: 10.2147/JIR.S431986. eCollection 2023.
Intervertebral disc degeneration (IDD) is considered the predominant cause of low back pain (LBP) and accounts for global disability and a substantial socioeconomic burden. Given the unsatisfactory outcomes of current treatment strategies, cartilage endplate-derived stem cells (CESCs) are increasingly used in intervertebral disc regeneration. However, comprehensive analyses on CESCs remain rare. Herein, we examined the biological functions and applications of CESCs in IDD.
PubMed, Embase, and Cochrane Library databases were searched to identify studies focused on CESCs. Relevant information from included studies was extracted. Descriptive statistics were performed. Correlation analysis was conducted to determine the relationship among Web of Science (WoS) citations, Dimensions, and Altmetric Attention Score (AAS).
Twenty-six studies were included in this study. Most studies (n=20) isolated CESCs from humans, followed by rats (n=5) and rabbits (n=1). Twenty studies were performed in vitro, and the remaining six were implemented both in vivo and in vitro. The findings of this study provide insight into the biological properties of CESCs and clarify their potential application for intervertebral disc regeneration. There was a very high correlation between WoS and Dimensions citation count (p<0.001, r=0.988).
This study, for the first time, elaborates biological features of CESCs and analyzes their potential applications in regenerating intervertebral discs. CESCs may be promising candidates for protecting the intervertebral disc from degeneration and contributing to intervertebral disc regeneration.
椎间盘退变（IDD）被认为是腰痛（LBP）的主要原因，造成了全球范围内的残疾和巨大的社会经济负担。鉴于当前治疗策略的效果不尽人意，软骨终板衍生干细胞（CESCs）越来越多地被用于椎间盘再生。然而，对CESCs的综合分析仍然很少。在此，我们研究了CESCs在IDD中的生物学功能和应用。
检索PubMed、Embase和Cochrane图书馆数据库，以识别关注CESCs的研究。提取纳入研究的相关信息。进行描述性统计。进行相关性分析以确定科学引文索引（WoS）引用次数、Dimensions和Altmetric关注度得分（AAS）之间的关系。
本研究纳入了26项研究。大多数研究（n = 20）从人类中分离出CESCs，其次是大鼠（n = 5）和兔子（n = 1）。20项研究在体外进行，其余6项在体内和体外均有实施。本研究结果为CESCs的生物学特性提供了见解，并阐明了它们在椎间盘再生中的潜在应用。WoS和Dimensions引用次数之间存在非常高的相关性（p < 0.001，r = 0.988）。
本研究首次阐述了CESCs的生物学特征，并分析了它们在椎间盘再生中的潜在应用。CESCs可能是保护椎间盘免于退变并促进椎间盘再生的有前途的候选者。
