Paul Bura Thlama, Hashi Hamza Abdirahman, Burhannuddin Nurul Najwa, Chung Eric Lim Teik, Jesse Faez Firdaus Abdullah, Lila Mohd Azmi Mohd, Haron Abd Wahid, Amat Azlan Che, Abba Yusuf, Maqbool Arsalan, Bhutto Khaleeq Ur Rehman, Isa Kamarulrizal Mat, Amira Nur Azhar, Odhah Mohammad Naji, Hambali Idris Umar, Norsidin Mohd Jefri
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, PMB 1069, Maiduguri 600233, Borno State, Nigeria.
Trop Life Sci Res. 2021 Jun;32(2):83-96. doi: 10.21315/tlsr2021.32.2.6. Epub 2021 Jun 29.
Caprine arthritis-encephalitis virus (CAEV) is a member of the genus lentivirus causing caprine arthritis-encephalitis (CAE), a chronic inflammatory condition affecting the lungs, joints, udder and central nervous system of small ruminants such as sheep and goats. CAE is distributed worldwide and is recognised as a significant cause of morbidity and decreased milk production in dairy goats. Earlier studies highlighted the clinicopathological features and supplied preliminary serological evidence for the existence of CAE among selected goat herds in Malaysia. Therefore, this study aims to provide further insights into the seroprevalence and contributing factors of CAE among sheep and goat herds in two states of Peninsular Malaysia. The blood samples and biodata were randomly collected from a total of 262 individual sheep (40) and goat (222) in seven smallholder farms. Blood sera were tested for specific anti-CAEV antibodies using Qayee-Bio CAEV sandwich-ELISA test kits according to standard procedures. Our results of the study revealed 21.4% (95% CI: 15.8-28.6) apparent and 20.6% (95% CI: 14.5-27.8) true seroprevalence with significant differences ( < 0.05) in seroconversion rates between the states, farms, production systems and breeds of small ruminants. The prevalence of CAE in the Malaysian Peninsular is a potential threat to the small ruminant industry and developing agricultural economy. Further studies are required to determine the genetic characteristics, distribution and risk factors of CAEV for effective prevention and control in Malaysia.
山羊关节炎-脑炎病毒（CAEV）是慢病毒属的成员，可引起山羊关节炎-脑炎（CAE），这是一种慢性炎症性疾病，会影响绵羊和山羊等小型反刍动物的肺部、关节、乳房和中枢神经系统。CAE在全球范围内均有分布，并且被认为是导致奶山羊发病和产奶量下降的重要原因。早期研究突出了临床病理特征，并为马来西亚部分山羊群中CAE的存在提供了初步血清学证据。因此，本研究旨在进一步深入了解马来西亚半岛两个州的绵羊和山羊群中CAE的血清流行率及影响因素。从七个小农户农场的总共262只个体绵羊（40只）和山羊（222只）中随机采集血样和生物数据。按照标准程序，使用Qayee-Bio CAEV夹心ELISA检测试剂盒检测血清中的特异性抗CAEV抗体。我们的研究结果显示，明显血清流行率为21.4%（95%置信区间：15.8 - 28.6），实际血清流行率为20.6%（95%置信区间：14.5 - 27.8），不同州、农场、生产系统和小型反刍动物品种之间的血清转化率存在显著差异（<0.05）。马来西亚半岛CAE的流行对小型反刍动物产业和发展中的农业经济构成潜在威胁。需要进一步研究以确定CAEV的遗传特征、分布和风险因素，以便在马来西亚进行有效的预防和控制。
