Evanti Annisa, Wargasetia Teresa Liliana, Gunadi Julia Windi
Master Program in Skin Ageing and Aesthetic Medicine, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
Department of Physiology, Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
Biomed Rep. 2025 Jun 4;23(2):131. doi: 10.3892/br.2025.2009. eCollection 2025 Aug.
Photoaging is a group of clinical and pathological manifestations caused by ultraviolet (UV) radiation, characterized by deep wrinkles, rough skin textures, dyspigmentation and disturbance of skin elasticity. UV radiation can cause skin damage due to reactive oxygen species (ROS) accumulation, which activates matrix metalloproteinase and increases collagen damage. One natural ingredient that has antioxidant properties by reducing ROS production is black cumin or () seeds; this effect is attributed to key components such as thymoquinone, flavonoids, essential fatty acids and essential minerals. The present review aimed to describe the potential ingredients of and its mechanism against photoaging. PubMed, ScienceDirect, Springer and Google Scholar databases were searched between 2014 and March 2024. The keywords were , black seed, thymoquinone and photoaging. The search was limited to articles in Indonesian and English. Based on the critical appraisal, the eligibility of the included articles was evaluated; nine eligible articles were selected. The authors indicated that and its active ingredient, thymoquinone, may have a role in preventing photoaging through various potential mechanisms, including its antioxidant and anti-inflammatory properties. Some studies have compared the effects of various types (oral and topical) of and thymoquinone with good outcomes. and thymoquinone may prevent photoaging by neutralizing UV-induced ROS accumulation. More studies are required to determine the exact mechanism of and thymoquinone as an alternative therapy for photoaging.
光老化是由紫外线（UV）辐射引起的一组临床和病理表现，其特征为深层皱纹、皮肤质地粗糙、色素沉着异常和皮肤弹性紊乱。紫外线辐射可因活性氧（ROS）积累而导致皮肤损伤，这会激活基质金属蛋白酶并增加胶原蛋白损伤。一种通过减少ROS生成而具有抗氧化特性的天然成分是黑孜然或黑种草籽；这种作用归因于百里醌、黄酮类化合物、必需脂肪酸和必需矿物质等关键成分。本综述旨在描述黑种草籽的潜在成分及其抗光老化机制。在2014年至2024年3月期间检索了PubMed、ScienceDirect、Springer和谷歌学术数据库。关键词为黑种草籽、黑籽、百里醌和光老化。检索仅限于印度尼西亚语和英语的文章。基于严格评价，评估了纳入文章的合格性；选择了9篇合格文章。作者指出，黑种草籽及其活性成分百里醌可能通过多种潜在机制在预防光老化中发挥作用，包括其抗氧化和抗炎特性。一些研究比较了不同类型（口服和局部应用）的黑种草籽和百里醌的效果，结果良好。黑种草籽和百里醌可能通过中和紫外线诱导的ROS积累来预防光老化。需要更多研究来确定黑种草籽和百里醌作为光老化替代疗法的确切机制。
