Syed Annuar Sharifah Nadhira, Kamaludin Nurul Farahana, Awang Normah, Chan Kok Meng
Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Chem. 2021 Jul 23;9:657599. doi: 10.3389/fchem.2021.657599. eCollection 2021.
Organotin(IV) compounds have wide applications in industrial and agricultural fields owing to their ability to act as poly(vinyl chloride) stabilizers and catalytic agents as well as their medicinal properties. Moreover, organotin(IV) compounds may have applications as antitumor, anti-inflammatory, antifungal, or antimicrobial agents based on the observation of synergistic effects following the binding of their respective ligands, resulting in the enhancement of their biological activities. In this review, we describe the antiproliferative activities of organotin(IV) compounds in various human cancer cell lines based on different types of ligands. We also discuss the molecular mechanisms through which organotin(IV) compounds induce cell death via apoptosis through the mitochondrial intrinsic pathway. Finally, we present the mechanisms of cell cycle arrest induced by organotin(IV) compounds. Our report provides a basis for studies of the antitumor activities of organotin(IV) compounds and highlights the potential applications of these compounds as anticancer metallodrugs with low toxicity and few side effects.
有机锡（IV）化合物由于能够作为聚氯乙烯稳定剂和催化剂以及具有药用特性，在工农业领域有着广泛应用。此外，基于观察到有机锡（IV）化合物各自的配体结合后产生的协同效应，从而增强其生物活性，它们可能具有作为抗肿瘤、抗炎、抗真菌或抗菌剂的应用。在本综述中，我们描述了基于不同类型配体的有机锡（IV）化合物在各种人类癌细胞系中的抗增殖活性。我们还讨论了有机锡（IV）化合物通过线粒体内在途径诱导细胞凋亡从而导致细胞死亡的分子机制。最后，我们阐述了有机锡（IV）化合物诱导细胞周期停滞的机制。我们的报告为有机锡（IV）化合物的抗肿瘤活性研究提供了基础，并突出了这些化合物作为低毒且副作用少的抗癌金属药物的潜在应用。
