巨噬细胞衍生外泌体的生物发生、生物学功能及应用
The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes.
作者信息
Shan Xiaoxiao, Zhang Caiyun, Mai Chutian, Hu Xuerui, Cheng Nuo, Chen Weidong, Peng Daiyin, Wang Lei, Ji Zhaojie, Xie Ying
机构信息
School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China.
Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China.
出版信息
Front Mol Biosci. 2021 Jul 21;8:715461. doi: 10.3389/fmolb.2021.715461. eCollection 2021.
Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.
巨噬细胞衍生的外泌体与炎症过程的调节有关。最近的研究表明，巨噬细胞衍生的外泌体促进了许多疾病的进展，如癌症、动脉粥样硬化、糖尿病和心力衰竭。这篇综述描述了巨噬细胞衍生的外泌体的生物发生及其在不同疾病中的生物学功能。此外，还描述了将巨噬细胞衍生的外泌体用作临床应用中药物、基因和蛋白质递送工具所面临的挑战。还讨论了巨噬细胞衍生的外泌体在疾病诊断和治疗中的应用。
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