Iqbal Sehar, Ali Inayat
Department of Environmental Health, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
National University of Medical Sciences, PWD Campus, Islamabad, Pakistan.
Heliyon. 2021 Jul 10;7(7):e07540. doi: 10.1016/j.heliyon.2021.e07540. eCollection 2021 Jul.
Zinc is an essential trace element involved in different physiological functions. During pregnancy, it plays a crucial role in healthy embryogenesis. This umbrella review, therefore, aimed to summarize the existing literature of meta-analyses evaluating the effect of maternal zinc supplementation or zinc status on maternal and neonatal outcomes. Two databases, PubMed and Scopus, were selected to search the available literature without any temporal restriction. The literature search was performed during October 2020 and a total of 192 records were identified through the literature search. After screening the titles and applying the inclusion/exclusion criteria, finally, 15 articles were included in this umbrella review. This umbrella review showed that maternal zinc supplements reduce the risk of preterm birth. Although no substantial effect of zinc supplements was found for other feto-maternal outcomes. Also, we found a significant relationship between low maternal zinc status and risk of pregnancy complications. Zinc supplements reduce the risk of preterm birth. Long-term interventions and cohort studies are needed for future research directions. Further studies and a thorough investigation will help to decide the recommended zinc dose or intake during pregnancy.
锌是一种参与多种生理功能的必需微量元素。在孕期，它在健康胚胎发育过程中起着至关重要的作用。因此，本系统综述旨在总结现有荟萃分析文献，评估孕期补充锌或锌状态对孕产妇及新生儿结局的影响。选择了两个数据库，即PubMed和Scopus，来检索无时间限制的可用文献。文献检索于2020年10月进行，通过文献检索共识别出192条记录。在筛选标题并应用纳入/排除标准后，最终有15篇文章纳入本系统综述。本系统综述表明，孕期补充锌可降低早产风险。尽管未发现补充锌对其他母婴结局有实质性影响。此外，我们发现孕产妇锌状态低下与妊娠并发症风险之间存在显著关联。补充锌可降低早产风险。未来的研究方向需要长期干预和队列研究。进一步的研究和深入调查将有助于确定孕期推荐的锌剂量或摄入量。
