Park Eun-Yeong, Oh Donghyeon, Park Sinyoung, Kim Wangyu, Kim Chulhong
Departments of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, South Korea.
APL Bioeng. 2021 Jul 30;5(3):031510. doi: 10.1063/5.0047660. eCollection 2021 Sep.
The phthalocyanine (Pc) and naphthalocyanine (Nc) nanoagents have drawn much attention as contrast agents for photoacoustic (PA) imaging due to their large extinction coefficients and long absorption wavelengths in the near-infrared region. Many investigations have been conducted to enhance Pc/Ncs' photophysical properties and address their poor solubility in an aqueous solution. Many diverse strategies have been adopted, including centric metal chelation, structure modification, and peripheral substitution. This review highlights recent advances on Pc/Nc-based PA agents and their extended use for multiplexed biomedical imaging, multimodal diagnostic imaging, and image-guided phototherapy.
酞菁（Pc）和萘酞菁（Nc）纳米剂因其在近红外区域具有大的消光系数和长吸收波长，作为光声（PA）成像的造影剂备受关注。人们进行了许多研究以增强Pc/Ncs的光物理性质并解决其在水溶液中溶解度低的问题。已采用了多种不同策略，包括中心金属螯合、结构修饰和外围取代。本综述重点介绍了基于Pc/Nc的PA剂的最新进展及其在多重生物医学成像、多模态诊断成像和图像引导光疗中的扩展应用。
