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从临床分离株金黄色葡萄球菌 C34847 中鉴定一种新型葡萄球菌盒式染色体，具有复合结构。

Characterizing a Novel Staphylococcal Cassette Chromosome with a Composite Structure from a Clinical Strain of Staphylococcus hominis, C34847.

机构信息

Centre for Antimicrobial Resistance, Alberta Health Services/Alberta Precision Laboratories/University of Calgary, Calgary, Alberta, Canada.

Department of Pathology & Laboratory Medicine, University of Calgarygrid.22072.35, Calgary, Alberta, Canada.

出版信息

Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0077721. doi: 10.1128/AAC.00777-21. Epub 2021 Aug 9.

DOI:10.1128/AAC.00777-21
PMID:34370581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8522780/
Abstract

Staphylococcal cassette chromosome (SCC) has predominantly been described in methicillin-resistant Staphylococcus aureus. However, studies have indicated that coagulase-negative staphylococci (CoNS) carry a larger diversity of SCC elements. We characterized a composite SCC element carrying an uncharacterized and type A gene combination, in conjunction with a secondary element bearing , from a clinical strain of Staphylococcus hominis. The element's complex structure points to a high degree of recombination occurring in SCC in CoNS.

摘要

葡萄球菌盒式染色体（SCC）主要存在于耐甲氧西林金黄色葡萄球菌中。然而，研究表明凝固酶阴性葡萄球菌（CoNS）携带更多种类的 SCC 元件。我们对来自临床分离的人葡萄球菌的一个复合 SCC 元件进行了特征描述，该元件携带一个未鉴定的和 A 型基因组合，以及一个带有 的次要元件。该元件的复杂结构表明 CoNS 中的 SCC 发生了高度重组。

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Infect Genet Evol. 2018 Jul;61:74-76. doi: 10.1016/j.meegid.2018.03.013. Epub 2018 Mar 19.
2
Extreme diversity and multiple SCCmec elements in coagulase-negative Staphylococcus found in the Clinic and Community in Beijing, China.在中国北京的临床和社区中发现的凝固酶阴性葡萄球菌具有极高的多样性和多种SCCmec元件。
Ann Clin Microbiol Antimicrob. 2017 Aug 22;16(1):57. doi: 10.1186/s12941-017-0231-z.
3
Novel Type XII Staphylococcal Cassette Chromosome mec Harboring a New Cassette Chromosome Recombinase, CcrC2.携带新型盒式染色体重组酶CcrC2的新型XII型葡萄球菌盒式染色体mec
Antimicrob Agents Chemother. 2015 Dec;59(12):7597-601. doi: 10.1128/AAC.01692-15. Epub 2015 Sep 28.
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Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus.移动元件驱动金黄色葡萄球菌核心基因组中的重组热点。
Nat Commun. 2014 May 23;5:3956. doi: 10.1038/ncomms4956.
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