从临床分离株金黄色葡萄球菌 C34847 中鉴定一种新型葡萄球菌盒式染色体，具有复合结构。
Characterizing a Novel Staphylococcal Cassette Chromosome with a Composite Structure from a Clinical Strain of Staphylococcus hominis, C34847.
机构信息
Centre for Antimicrobial Resistance, Alberta Health Services/Alberta Precision Laboratories/University of Calgary, Calgary, Alberta, Canada.
Department of Pathology & Laboratory Medicine, University of Calgarygrid.22072.35, Calgary, Alberta, Canada.
出版信息
Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0077721. doi: 10.1128/AAC.00777-21. Epub 2021 Aug 9.
Abstract
Staphylococcal cassette chromosome (SCC) has predominantly been described in methicillin-resistant Staphylococcus aureus. However, studies have indicated that coagulase-negative staphylococci (CoNS) carry a larger diversity of SCC elements. We characterized a composite SCC element carrying an uncharacterized and type A gene combination, in conjunction with a secondary element bearing , from a clinical strain of Staphylococcus hominis. The element's complex structure points to a high degree of recombination occurring in SCC in CoNS.
摘要
葡萄球菌盒式染色体（SCC）主要存在于耐甲氧西林金黄色葡萄球菌中。然而，研究表明凝固酶阴性葡萄球菌（CoNS）携带更多种类的 SCC 元件。我们对来自临床分离的人葡萄球菌的一个复合 SCC 元件进行了特征描述，该元件携带一个未鉴定的和 A 型基因组合，以及一个带有 的次要元件。该元件的复杂结构表明 CoNS 中的 SCC 发生了高度重组。
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