Postgraduate Program in Natural Synthetic and Bioactive Products, Heath Sciences Center, Federal University of Paraíba - Campus I, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Department of Paediatrics and Genetics, Medical Science Center, Federal University of Paraíba - Campus I, 58051-900, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Curr Neuropharmacol. 2022;20(10):1834-1849. doi: 10.2174/1570159X19666210809102547.
Autism spectrum disorder (ASD) is a neurological condition that directly affects brain functions and can culminate in delayed intellectual development, problems in verbal communication, difficulties in social interaction, and stereotyped behaviors. Its etiology reveals a genetic basis that can be strongly influenced by socio-environmental factors. Ion channels controlled by ligand voltage-activated calcium, sodium, and potassium channels may play important roles in modulating sensory and cognitive responses, and their dysfunctions may be closely associated with neurodevelopmental disorders such as ASD. This is due to ionic flow, which is of paramount importance to maintaining physiological conditions in the central nervous system and triggers action potentials, gene expression, and cell signaling. However, since ASD is a multifactorial disease, treatment is directed only to secondary symptoms. Therefore, this research aims to gather evidence concerning the principal pathophysiological mechanisms involving ion channels in order to recognize their importance as therapeutic targets for the treatment of central and secondary ASD symptoms.
自闭症谱系障碍（ASD）是一种神经系统疾病，直接影响大脑功能，可能导致智力发育迟缓、语言交流问题、社交互动困难和刻板行为。其病因揭示了遗传基础，而遗传基础可能受到社会环境因素的强烈影响。配体电压激活钙、钠和钾通道控制的离子通道可能在调节感觉和认知反应方面发挥重要作用，其功能障碍可能与自闭症谱系障碍等神经发育障碍密切相关。这是因为离子流对于维持中枢神经系统的生理状态至关重要，并且可以引发动作电位、基因表达和细胞信号转导。然而，由于自闭症谱系障碍是一种多因素疾病，因此治疗仅针对次要症状。因此，本研究旨在收集涉及离子通道的主要病理生理机制的证据，以认识到它们作为治疗中枢和次要自闭症谱系障碍症状的治疗靶点的重要性。
