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多方面机制介导胱氨酸饥饿诱导的铁死亡。

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis.

机构信息

Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.

School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

出版信息

Nat Commun. 2021 Aug 9;12(1):4792. doi: 10.1038/s41467-021-25159-5.

DOI:10.1038/s41467-021-25159-5
PMID:34373463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8352933/
Abstract

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

摘要

半胱氨酸/谷胱甘肽 (GSH)/谷胱甘肽过氧化物酶 4 (GPX4) 轴是触发铁死亡级联反应和抑制肿瘤生长的最常靶向途径。最近的两项研究除了表明 GSH 合成受损外，还提出了胱氨酸饥饿诱导铁死亡的其他机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efa5/8352933/c436a7bfa593/41467_2021_25159_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efa5/8352933/c436a7bfa593/41467_2021_25159_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efa5/8352933/c436a7bfa593/41467_2021_25159_Fig1_HTML.jpg

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