Pixley S K, Nieto-Sampedro M, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
J Neurosci Res. 1987;18(3):402-6. doi: 10.1002/jnr.490180304.
Astrocytes from either fetal or newborn rat brain adhered preferentially to surfaces coated with active laminin. Neurites from septal neurons did not show a preference for active over inactive laminin. However, when given a choice between laminin and an astrocytic surface, septal cells preferred to extend neurites over astroglial processes. Hence, laminin paths can guide astrocyte migration, which, in turn, can guide neurite elongation.
来自胎鼠或新生鼠大脑的星形胶质细胞优先黏附于涂有活性层粘连蛋白的表面。来自隔区神经元的神经突对活性层粘连蛋白和非活性层粘连蛋白没有偏好。然而，当在层粘连蛋白和星形胶质细胞表面之间做出选择时，隔区细胞更倾向于在星形胶质细胞突起上延伸神经突。因此，层粘连蛋白路径可以引导星形胶质细胞迁移，而星形胶质细胞迁移又可以引导神经突伸长。
