Center for Immunological and Inflammatory Diseases, Department of Medicine.
Food Allergy Center, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Curr Opin Allergy Clin Immunol. 2021 Oct 1;21(5):442-447. doi: 10.1097/ACI.0000000000000774.
Utilization of basophil activation in the diagnosis and monitoring of food allergy has gained increasing recognition. An ex-vivo functional assay, basophil activation reflects clinical reactivity, thereby providing clinically relevant insights. Moreover, as a biomarker of reactivity and tolerance, basophil activation testing (BAT) may provide a useful tool for management of food allergies. Despite its utility, significant limitations of BAT have prevented widespread use. Addressing these limitations will increase the future application and adoption of BAT in food allergy.
A number of clinical trials in the past few years have demonstrated the use of BAT in the diagnosis and treatment of food allergy. Specifically, BAT has been found to be a biomarker of tolerance.
Basophil activation testing is an effective biomarker for diagnosis and monitoring of food allergy.
嗜碱性粒细胞激活在食物过敏的诊断和监测中的应用得到了越来越多的认可。体外功能检测，嗜碱性粒细胞激活反映了临床反应性，从而提供了具有临床相关性的见解。此外，作为反应性和耐受性的生物标志物，嗜碱性粒细胞激活试验（BAT）可能为食物过敏的管理提供有用的工具。尽管具有实用性，但 BAT 的重大局限性限制了其广泛应用。解决这些局限性将增加未来 BAT 在食物过敏中的应用和采用。
过去几年中的多项临床试验证明了 BAT 在食物过敏的诊断和治疗中的应用。具体来说，BAT 已被发现是耐受性的生物标志物。
嗜碱性粒细胞激活测试是诊断和监测食物过敏的有效生物标志物。
