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A potential synthetic lethal strategy with PARP inhibitors: perspective on 'Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP'.

作者信息

Hao Qian, Lu Hua, Zhou Xiang

机构信息

Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

J Mol Cell Biol. 2021 Dec 6;13(9):690-692. doi: 10.1093/jmcb/mjab049.

DOI:10.1093/jmcb/mjab049
PMID:34375408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8648391/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee92/8648391/7ae0cf7eb7e9/mjab049f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee92/8648391/7ae0cf7eb7e9/mjab049f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee92/8648391/7ae0cf7eb7e9/mjab049f1.jpg

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本文引用的文献

1
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.长非编码 RNA RMRP 使抑癌基因 p53 失活。
Proc Natl Acad Sci U S A. 2021 Jul 20;118(29). doi: 10.1073/pnas.2026813118.
2
PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer.聚腺苷二磷酸核糖聚合酶抑制剂通过抑制 SLC7A11 促进铁死亡，并与 BRCA 功能正常的卵巢癌中的铁死亡诱导剂协同作用。
Redox Biol. 2021 Jun;42:101928. doi: 10.1016/j.redox.2021.101928. Epub 2021 Mar 5.
3
Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity.
小儿急性起病神经精神综合征或神经发育障碍急性行为倒退中DNA损伤修复基因的超罕见变异
Dev Neurosci. 2024 Oct 11:1-20. doi: 10.1159/000541908.
4
The ARTS of p53-dependent mitochondrial apoptosis.p53 依赖性线粒体细胞凋亡的机制。
J Mol Cell Biol. 2023 Mar 29;14(10). doi: 10.1093/jmcb/mjac074.
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Olaparib Induces RPL5/RPL11-Dependent p53 Activation Nucleolar Stress.奥拉帕尼诱导RPL5/RPL11依赖的p53激活 核仁应激。
Front Oncol. 2022 Jun 3;12:821366. doi: 10.3389/fonc.2022.821366. eCollection 2022.
6
Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.癌症中野生型和突变型 p53 的治疗性靶向的先进策略。
Biomolecules. 2022 Apr 6;12(4):548. doi: 10.3390/biom12040548.
7
The emerging role of long noncoding RNA RMRP in cancer development and targeted therapy.长链非编码RNA RMRP在癌症发展和靶向治疗中的新作用
Cancer Biol Med. 2022 Jan 26;19(2):140-6. doi: 10.20892/j.issn.2095-3941.2021.0577.
在结直肠癌的临床前模型中，除同源重组缺陷外，对 PARP 抑制敏感的分子相关性指向野生型 TP53 活性。
EBioMedicine. 2020 Sep;59:102923. doi: 10.1016/j.ebiom.2020.102923. Epub 2020 Aug 13.
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Blinded by the Light: The Growing Complexity of p53.被光蒙蔽：p53日益复杂的情况
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