Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA; Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, China.
Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA; Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Skaggs Graduate School, The Scripps Research Institute, Jupiter, FL 33458, USA.
Curr Biol. 2021 Aug 9;31(15):R946-R947. doi: 10.1016/j.cub.2021.06.046.
Many animals rely on taste to identify nutritious foods and to avoid the consumption of harmful substances. The tastes of macronutrients, as well as of non-caloric micronutrients such as sodium and calcium, contribute to the regulation of ingestive behavior. Whether vitamins also affect feeding behavior through taste is less clear. Here, we show that the fly Drosophila melanogaster has a strong preference for consuming a vitamin-containing diet: both sexes show a preference for folic acid, whereas only females show a preference for riboflavin. Females show a preference with vitamin concentrations as low as ∼10 nM - at least 50,000-fold lower than the concentration needed for sucrose preference. This female vitamin preference requires inputs from external and internal taste organs, suggesting that post-ingestive signals, in the absence of gustatory input, are insufficient to actuate preferential consumption of vitamin-containing diets. Our studies demonstrate that vitamin perception is an important determinant of feeding behavior.
许多动物依赖味觉来识别有营养的食物和避免摄入有害物质。宏量营养素的味道，以及非热量微量营养素（如钠和钙）的味道，有助于调节摄食行为。维生素是否也通过味觉影响进食行为则不太清楚。在这里，我们表明，果蝇 Drosophila melanogaster 强烈倾向于食用含维生素的饮食：两性都表现出对叶酸的偏好，而只有雌性表现出对核黄素的偏好。雌性对维生素的浓度低至约 10 nM 就表现出偏好 - 至少比蔗糖偏好所需的浓度低 50,000 倍。这种雌性维生素偏好需要来自外部和内部味觉器官的输入，这表明在没有味觉输入的情况下，摄取后的信号不足以促使偏爱含有维生素的饮食。我们的研究表明，维生素感知是进食行为的一个重要决定因素。
