Sudo A
National Institute of Industrial Health, Kawasaki, Japan.
Jpn J Pharmacol. 1987 Oct;45(2):197-201. doi: 10.1254/jjp.45.197.
Adrenaline is known to increase in extra-adrenal peripheral organs as well as urine and plasma in the rat after swimming stress. In order to clarify the physiological significance of adrenaline in stress responses, the origin and location of adrenaline in the peripheral organs were examined by measuring adrenaline in the heart, spleen, submaxillary gland and some other organs after adrenalectomy or guanethidine treatment. After bilateral adrenalectomy, adrenaline in the peripheral organs mostly disappeared. Swimming stress caused no increase in the adrenaline content of the organs in the adrenalectomized rats, while a marked increase was observed in the sham-operated animals. In guanethidine-treated rats, the adrenaline content of the peripheral organs was extremely low as compared to that in the saline-treated animals, and the swimming-induced increase in adrenaline level in the organs was greatly suppressed. These observations suggest that the organ adrenaline, which exists in sympathetic nerve endings, is mostly derived from the adrenal gland. It is considered that adrenaline would be involved in sympathetic neurotransmission, especially under stressful conditions.
已知在大鼠经受游泳应激后，肾上腺外的外周器官以及尿液和血浆中的肾上腺素会增加。为了阐明肾上腺素在应激反应中的生理意义，通过在肾上腺切除或胍乙啶处理后测量心脏、脾脏、颌下腺和其他一些器官中的肾上腺素，来研究外周器官中肾上腺素的来源和位置。双侧肾上腺切除后，外周器官中的肾上腺素大多消失。游泳应激并未使肾上腺切除大鼠器官中的肾上腺素含量增加，而在假手术动物中则观察到显著增加。在胍乙啶处理的大鼠中，外周器官中的肾上腺素含量与生理盐水处理的动物相比极低，并且游泳诱导的器官中肾上腺素水平的增加受到极大抑制。这些观察结果表明，存在于交感神经末梢的器官肾上腺素大多源自肾上腺。据认为，肾上腺素会参与交感神经传递，尤其是在应激条件下。
