Sudo A
National Institute of Industrial Health, Kawasaki, Japan.
Life Sci. 1987 Nov 30;41(22):2477-84. doi: 10.1016/0024-3205(87)90674-6.
In order to examine the origin and location of adrenaline in peripheral organs of mammals, adrenaline and noradrenaline were measured in several organs of the rat after adrenalectomy, guanethidine treatment and imipramine injection. One week after bilateral adrenalectomy, adrenaline disappeared almost completely from the heart, spleen and submaxillary gland. Chronic administration of guanethidine caused decreases in both noradrenaline and adrenaline in the peripheral organs. Injection of imipramine induced a reduction of adrenaline concentration in the spleen and submaxillary gland. It is considered that adrenaline in the peripheral organs of mammals is mostly derived from the adrenal gland and that circulating adrenaline is taken up by sympathetic nerve endings in the organs. The adrenaline content of the peripheral organs increased after electric foot-shock and changed according to the time of day. The peak of the circadian rhythm appeared about 6 hours after the peak of the urinary adrenaline rhythm. These findings suggest that adrenaline in body organs plays some role in the responses of the sympathetic nervous system to stressful conditions or even to daily activities.
为了研究哺乳动物外周器官中肾上腺素的来源和分布位置，在大鼠双侧肾上腺切除、胍乙啶处理和丙咪嗪注射后，测定了大鼠多个器官中的肾上腺素和去甲肾上腺素含量。双侧肾上腺切除术后一周，心脏、脾脏和颌下腺中的肾上腺素几乎完全消失。长期给予胍乙啶会导致外周器官中去甲肾上腺素和肾上腺素含量均降低。注射丙咪嗪会使脾脏和颌下腺中的肾上腺素浓度降低。据认为，哺乳动物外周器官中的肾上腺素主要来源于肾上腺，循环中的肾上腺素会被器官中的交感神经末梢摄取。电休克足部刺激后，外周器官中的肾上腺素含量增加，并随一天中的时间变化而改变。昼夜节律的峰值出现在尿肾上腺素节律峰值后约6小时。这些发现表明，体内器官中的肾上腺素在交感神经系统对压力状况甚至日常活动的反应中发挥着一定作用。
