• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

蛇床子素：来源、生物活性及修饰研究进展综述

Osthole: an overview of its sources, biological activities, and modification development.

作者信息

Sun Mingna, Sun Mingjiao, Zhang Jianye

机构信息

Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, 511436 P. R. China.

The State Key Laboratory of Respiratory Disease & NMPA Key Laboratory for Clinical Research and Evaluation of Drug for Thoracic Diseases, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, 511436 P. R. China.

出版信息

Med Chem Res. 2021;30(10):1767-1794. doi: 10.1007/s00044-021-02775-w. Epub 2021 Aug 5.

DOI:10.1007/s00044-021-02775-w
PMID:34376964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8341555/
Abstract

Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants such as and . It can be obtained extraction and separation from plants or total synthesis. Plenty of experiments have suggested that osthole exhibited multiple biological activities covering antitumor, anti-inflammatory, neuroprotective, osteogenic, cardiovascular protective, antimicrobial, and antiparasitic activities. In addition, there has been some research done on the optimization and modification of osthole. This article summarizes the comprehensive information regarding the sources and modification progress of osthole. It also introduces the up-to-date biological activities of osthole, which could be of great value for its use in future research.

摘要

蛇床子素，又称欧前胡素，是一种香豆素衍生物，存在于多种药用植物如[此处原文缺失植物名称]等中。它可以通过从植物中提取分离或全合成获得。大量实验表明，蛇床子素具有多种生物活性，包括抗肿瘤、抗炎、神经保护、成骨、心血管保护、抗菌和抗寄生虫活性。此外，对蛇床子素的优化和修饰也有一些研究。本文总结了关于蛇床子素来源和修饰进展的全面信息。还介绍了蛇床子素最新的生物活性，这对其在未来研究中的应用可能具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/a97375e27ef4/44_2021_2775_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/738f4e27ff94/44_2021_2775_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8eeca3b3db3f/44_2021_2775_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/20ad7fafdde8/44_2021_2775_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/82c8982be6f1/44_2021_2775_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/ce14f430ab38/44_2021_2775_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/e1234270a05d/44_2021_2775_Sch4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8a39b6157436/44_2021_2775_Sch5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/d1f02157d282/44_2021_2775_Sch6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/94ff889cb847/44_2021_2775_Sch7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/777fd8164ccf/44_2021_2775_Sch8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/4c5d23122164/44_2021_2775_Sch9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/4c0a7f761fa5/44_2021_2775_Sch10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/0ae08ba1d260/44_2021_2775_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/7c15373f3cb0/44_2021_2775_Sch11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/c3a9c027ca61/44_2021_2775_Sch12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/302ad6990235/44_2021_2775_Sch13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8d78a681a463/44_2021_2775_Sch14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/354039262c24/44_2021_2775_Sch15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/29b41e4beffc/44_2021_2775_Sch16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/693f7be64c8a/44_2021_2775_Sch17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/deec0e15f9ee/44_2021_2775_Sch18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/f4719d150038/44_2021_2775_Sch19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/cf3b78751366/44_2021_2775_Sch20_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/64ad5063a76a/44_2021_2775_Sch21_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/2d16525894a9/44_2021_2775_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8e1609344704/44_2021_2775_Sch22_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8737e98e6004/44_2021_2775_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/b0ac0e814bb5/44_2021_2775_Sch23_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/b7b3bfc989de/44_2021_2775_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/d7de8e68ccd6/44_2021_2775_Sch24_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/a97375e27ef4/44_2021_2775_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/738f4e27ff94/44_2021_2775_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8eeca3b3db3f/44_2021_2775_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/20ad7fafdde8/44_2021_2775_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/82c8982be6f1/44_2021_2775_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/ce14f430ab38/44_2021_2775_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/e1234270a05d/44_2021_2775_Sch4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8a39b6157436/44_2021_2775_Sch5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/d1f02157d282/44_2021_2775_Sch6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/94ff889cb847/44_2021_2775_Sch7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/777fd8164ccf/44_2021_2775_Sch8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/4c5d23122164/44_2021_2775_Sch9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/4c0a7f761fa5/44_2021_2775_Sch10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/0ae08ba1d260/44_2021_2775_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/7c15373f3cb0/44_2021_2775_Sch11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/c3a9c027ca61/44_2021_2775_Sch12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/302ad6990235/44_2021_2775_Sch13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8d78a681a463/44_2021_2775_Sch14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/354039262c24/44_2021_2775_Sch15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/29b41e4beffc/44_2021_2775_Sch16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/693f7be64c8a/44_2021_2775_Sch17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/deec0e15f9ee/44_2021_2775_Sch18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/f4719d150038/44_2021_2775_Sch19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/cf3b78751366/44_2021_2775_Sch20_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/64ad5063a76a/44_2021_2775_Sch21_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/2d16525894a9/44_2021_2775_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8e1609344704/44_2021_2775_Sch22_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/8737e98e6004/44_2021_2775_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/b0ac0e814bb5/44_2021_2775_Sch23_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/b7b3bfc989de/44_2021_2775_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/d7de8e68ccd6/44_2021_2775_Sch24_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a3d/8341555/a97375e27ef4/44_2021_2775_Fig7_HTML.jpg

相似文献

1
Osthole: an overview of its sources, biological activities, and modification development.蛇床子素：来源、生物活性及修饰研究进展综述
Med Chem Res. 2021;30(10):1767-1794. doi: 10.1007/s00044-021-02775-w. Epub 2021 Aug 5.
2
Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.蛇床子素：关于其生物活性、药理特性及作为替代医学潜力的综述
Evid Based Complement Alternat Med. 2015;2015:919616. doi: 10.1155/2015/919616. Epub 2015 Jul 13.
3
Pharmacological features of osthole.蛇床子素的药理学特性
Postepy Hig Med Dosw (Online). 2017 May 15;71(0):411-421. doi: 10.5604/01.3001.0010.3824.
4
Osthole: Synthesis, Structural Modifications, and Biological Properties.蛇床子素：合成、结构修饰及生物活性。
Mini Rev Med Chem. 2022;22(16):2124-2137. doi: 10.2174/1389557522666220214101231.
5
Review on the protective activity of osthole against the pathogenesis of osteoporosis.蛇床子素对骨质疏松症发病机制的保护作用综述
Front Pharmacol. 2023 Aug 23;14:1236893. doi: 10.3389/fphar.2023.1236893. eCollection 2023.
6
The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways.蛇床子素，蛇床子（Cnidium monnieri（L.）Cuss）中的主要天然香豆素，通过阻断 NF-κB 和 MAPK/p38 通路的激活，具有体外和体内抗炎作用。
Phytomedicine. 2019 May;58:152864. doi: 10.1016/j.phymed.2019.152864. Epub 2019 Feb 18.
7
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities.蛇床子素：一种具有潜在抗癌、抗氧化和抗炎活性的多功能天然化合物。
Mini Rev Med Chem. 2021;21(18):2747-2763. doi: 10.2174/1389557520666200709175948.
8
Inhibitory Effect of Osthole from on Tobacco Mosaic Virus (TMV) Infection in .蛇床子素对烟草花叶病毒（TMV）感染的抑制作用。
Molecules. 2019 Dec 24;25(1):65. doi: 10.3390/molecules25010065.
9
Protective effects of osthole against myocardial ischemia/reperfusion injury in rats.蛇床子素对大鼠心肌缺血/再灌注损伤的保护作用。
Int J Mol Med. 2013 Aug;32(2):365-72. doi: 10.3892/ijmm.2013.1386. Epub 2013 May 21.
10
Construction of oxime ester derivatives of osthole from Cnidium monnieri, and evaluation of their agricultural activities and control efficiency.从蛇床子中构建花椒毒素肟酯衍生物，并评价其农业活性和防治效率。
Pest Manag Sci. 2020 Nov;76(11):3560-3567. doi: 10.1002/ps.6056. Epub 2020 Sep 9.

引用本文的文献

1
Unveiling the therapeutic potential of prenyl motif-containing derivatives: a key structural fragment for designing antidepressant compounds.揭示含异戊二烯基基序衍生物的治疗潜力：设计抗抑郁化合物的关键结构片段。
RSC Med Chem. 2025 Jul 3. doi: 10.1039/d5md00473j.
2
Natural products target programmed cell death signaling mechanisms to treat colorectal cancer.天然产物靶向程序性细胞死亡信号传导机制以治疗结直肠癌。
Front Pharmacol. 2025 Apr 24;16:1565332. doi: 10.3389/fphar.2025.1565332. eCollection 2025.
3
Osthole mitigates the myofibroblast properties in oral submucous fibrosis by suppressing the TGF-β/smad2 signaling pathway and NCK-AS1 expression.
蛇床子素通过抑制TGF-β/smad2信号通路和NCK-AS1表达减轻口腔黏膜下纤维化中的肌成纤维细胞特性。
J Dent Sci. 2025 Apr;20(2):911-918. doi: 10.1016/j.jds.2024.08.021. Epub 2024 Sep 8.
4
Immunomodulatory Effects of Selected Non-Nutritive Bioactive Compounds and Their Role in Optimal Nutrition.特定非营养性生物活性化合物的免疫调节作用及其在最佳营养中的作用。
Curr Issues Mol Biol. 2025 Jan 31;47(2):89. doi: 10.3390/cimb47020089.
5
Formulation of Ethyl Cellulose Nanoparticles Encapsulated with Osthole Provides Long-Lasting Plant Protection against a Major Pest Mite.蛇床子素包封的乙基纤维素纳米粒制剂对主要害虫螨提供持久的植物保护。
ACS Appl Mater Interfaces. 2025 Feb 12;17(6):8987-8999. doi: 10.1021/acsami.4c18094. Epub 2025 Jan 29.
6
Identification of immunostimulatory activities and active compounds from sequentially extracted fractions of rhizosphere fungal fermentation broth of Koidz. rhizomes.从类脐孢根茎根际真菌发酵液的顺序提取级分中鉴定免疫刺激活性和活性化合物。
Front Pharmacol. 2024 Dec 20;15:1460614. doi: 10.3389/fphar.2024.1460614. eCollection 2024.
7
Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis.植物源天然产物抗乳腺癌骨转移的作用及机制研究综述
Heliyon. 2024 Sep 13;10(18):e37894. doi: 10.1016/j.heliyon.2024.e37894. eCollection 2024 Sep 30.
8
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products.链格孢属物种对选定次生代谢产物的生物转化以及生物转化产物在制药、食品和农业方面的应用。
Nat Prod Bioprospect. 2024 Aug 19;14(1):46. doi: 10.1007/s13659-024-00469-5.
9
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure-Activity Relationship (SAR) of coumarins.基于香豆素的构效关系（SAR）探讨胡芦巴属植物的民族医学、植物化学和药理学特性的综述。
Daru. 2024 Dec;32(2):825-899. doi: 10.1007/s40199-024-00530-1. Epub 2024 Aug 19.
10
Role of microglia in diabetic neuropathic pain.小胶质细胞在糖尿病性神经病理性疼痛中的作用。
Front Cell Dev Biol. 2024 Jul 29;12:1421191. doi: 10.3389/fcell.2024.1421191. eCollection 2024.