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游泳池中N-亚硝基二甲胺(NDMA)的出现:综述。

The Occurrence of -nitrosodimethylamine (NDMA) in Swimming Pools: An Overview.

作者信息

Mustapha Saheed, Jimoh Tijani, Ndamitso Muhammed, Abdulkareem Saka Ambali, Taye Shuaib Damola, Mohammed Abdul Kabir, Amigun Azeezah Taiwo

机构信息

Department of Chemistry, Federal University of Technology, Minna, Nigeria.

Nanotechnology Research Group, Center for Genetic Engineering and Biotechnology, Federal University of Technology, Minna, Niger, Nigeria.

出版信息

Environ Health Insights. 2021 Aug 1;15:11786302211036520. doi: 10.1177/11786302211036520. eCollection 2021.

Abstract

The occurrence of several disinfectant byproducts has been investigated in swimming pools. Until now, there are only a few studies on nitrosamine, particularly -nitrosodimethylamine in swimming pool water. This could be due to the lack of a suitable method that is sensitive enough for the measurement of -nitrosodimethylamine in pool waters. Other disinfectant byproducts formed in pool water widely documented are trihalomethanes, haloacetic acids, halonitromethanes, and chloramines but inadequate information on -nitrosodimethylamine. This paper provides a review of the nitrogenous disinfectant byproduct in swimming pools and its health implications. Anthropogenic substances introduced by swimmers such as sweat, lotions, and urine contribute to the formation of -nitrosodimethylamine. The reaction of secondary amines such as dimethylamine with mono/dichloroamines produced dimethyl hydrazine and further undergo oxidation to form -nitrosodimethylamine. The reaction of chlorine and other disinfectants with these anthropogenic sources in swimming pools cause cancer and asthma in human tissues. Thus, the assessment of -nitrosodimethylamine in the swimming pool is less well documented. Therefore, the health consequences, mutagenic, and genotoxic potentials of -nitrosodimethylamine should be the focus of more research studies.

摘要

已对游泳池中几种消毒副产物的出现情况进行了调查。到目前为止,关于亚硝胺,特别是游泳池水中的二甲基亚硝胺的研究很少。这可能是由于缺乏一种对泳池水中二甲基亚硝胺的测量足够灵敏的合适方法。泳池水中形成的其他有大量记录的消毒副产物是三卤甲烷、卤乙酸、卤代硝基甲烷和氯胺,但关于二甲基亚硝胺的信息不足。本文综述了游泳池中的含氮消毒副产物及其对健康的影响。游泳者带入的人为物质,如汗液、乳液和尿液,会促使二甲基亚硝胺的形成。二甲胺等仲胺与一氯胺/二氯胺反应生成二甲基肼,进一步氧化形成二甲基亚硝胺。游泳池中氯和其他消毒剂与这些人为来源的反应会导致人体组织患癌症和哮喘。因此,对游泳池中二甲基亚硝胺的评估记录较少。因此,二甲基亚硝胺的健康后果、致突变性和遗传毒性潜力应成为更多研究的重点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60ed/8335839/071a2ee1c90c/10.1177_11786302211036520-fig1.jpg

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