Del Bigio M R, Bruni J E
Department of Anatomy, University of Manitoba, Winnipeg, Canada.
Pediatr Neurosci. 1987;13(2):67-71. doi: 10.1159/000120303.
Epidural intracranial pressure (ICP) was monitored chronically for up to 6 weeks in conscious, unrestrained rabbits. Hydrocephalus was induced by injecting viscous silicone oil into the cisterna magna. Following injection, ICP remained significantly elevated for only 2 days. Thereafter, the baseline ICP of hydrocephalic rabbits returned to control values. During the hydrocephalic period, however, ICP exhibited instability and transient elevations. ICP characteristics of this model of experimental hydrocephalus resemble those of chronically hydrocephalic humans.
在清醒、不受束缚的家兔中，对硬膜外颅内压（ICP）进行了长达6周的长期监测。通过向大池内注射粘性硅油诱导脑积水。注射后，ICP仅在2天内显著升高。此后，脑积水家兔的基线ICP恢复到对照值。然而，在脑积水期间，ICP表现出不稳定和短暂升高。这种实验性脑积水模型的ICP特征与慢性脑积水患者的特征相似。
