突破性 SARS-CoV-2 感染后的疫苗接种：批判性回顾。
Breakthrough SARS-CoV-2 infections after vaccination: a critical review.
机构信息
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Hum Vaccin Immunother. 2022 Nov 30;18(5):2051412. doi: 10.1080/21645515.2022.2051412. Epub 2022 Mar 18.
Abstract
At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
摘要
在当前大流行开始时，人们认为严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染会诱导终身免疫，且不太可能再次感染。然而，在先前感染的患者中记录了几例再次感染病例后，人们意识到这是一个错误的假设，这种体液免疫的减弱引起了人们的高度关注。因此，针对感染的长期和持久的疫苗诱导抗体保护也成为一个挑战，因为在完全接种疫苗的个体中已经发现了几例 COVID-19 突破性感染。本综述讨论了接种疫苗后发生的突破性 COVID-19 感染的现有证据。
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