Department of Psychology, University of Fribourg, Fribourg, Switzerland.
Department of Social Neuroscience and Social Psychology, Institute of Psychology, University of Bern, Bern, Switzerland.
J Med Internet Res. 2024 Jul 31;26:e51120. doi: 10.2196/51120.
Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.
This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.
In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate, heart rate variability, and objectively assessed the duration of menstrual cycle phases in menstruating participants to assess the effects of COVID-19 vaccination.
The recorded physiological signals demonstrated short-term increases in breathing rate and heart rate after COVID-19 vaccination followed by a prompt rebound to baseline levels likely reflecting biological mechanisms accompanying the immune response to vaccination. No sex differences were evident in the measured physiological responses. In menstruating participants, we found a 0.8% decrease in the duration of the menstrual phase following vaccination.
The observed short-term changes suggest that COVID-19 vaccines are not associated with long-term biophysical issues. Taken together, our work provides valuable insights into continuous fluctuations of physiological responses to vaccination and highlights the importance of digital solutions in health care.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1186/s13063-021-05241-5.
疫苗的快速开发和应用是控制 COVID-19 大流行的关键步骤。全面了解这些疫苗对人体的生理反应对于建立对医学的信任至关重要。
本研究旨在调查 COVID-19 疫苗接种前后 4 项生理参数和月经周期各阶段持续时间的时间动态变化。
在一项前瞻性试验中，荷兰的 17825 名成年人在手腕上佩戴了一个医疗设备，最长可达 9 个月。该设备记录了他们的生理信号，并与配套的智能手机应用程序同步。通过多级二次回归，我们检查了可穿戴设备记录的呼吸率、手腕皮肤温度、心率、心率变异性的变化，并客观评估了处于经期的参与者的月经周期各阶段的持续时间，以评估 COVID-19 疫苗接种的效果。
记录的生理信号显示，COVID-19 疫苗接种后呼吸率和心率短期增加，随后迅速反弹至基线水平，这可能反映了伴随疫苗接种免疫反应的生物学机制。在测量的生理反应中，没有发现性别差异。在处于经期的参与者中，我们发现接种疫苗后月经周期持续时间减少了 0.8%。
观察到的短期变化表明 COVID-19 疫苗不会引起长期的生物物理问题。总的来说，我们的工作为疫苗接种后生理反应的连续波动提供了有价值的见解，并强调了数字解决方案在医疗保健中的重要性。
国际注册报告识别码（IRRID）：RR2-10.1186/s13063-021-05241-5。
