新喀里多尼亚的嗜酸性粒细胞性脑膜炎：广州管圆线虫的作用？
Eosinophilic meningitis in New Caledonia: The role of Angiostrongylus cantonensis?
作者信息
Melot Bénédicte, Delvallez Gauthier, Gourinat Ann-Claire, Molko Nicolas, Goarant Cyrille, Ducrot Yves-Marie, Huguon Emilie, Cazorla Cécile, Chauvet Martine, Biron Antoine, Colot Julien
机构信息
INSERM, UMRS 1142 LIMICS, Sorbonne Université, Paris, France.
Experimental Bacteriology Group, Pasteur Institute in New Caledonia, New Caledonia, France.
出版信息
PLoS One. 2021 Aug 12;16(8):e0254964. doi: 10.1371/journal.pone.0254964. eCollection 2021.
INTRODUCTION
Eosinophilic meningitis is a rare form of meningitis with sequelae or death occurring in approximately 2-3% of cases. The most frequent etiological agent is the parasite Angiostrongylus cantonensis. The aim of this study was to characterize New Caledonian cases and to assess the extent to which of A. cantonensis was involved.
MATERIAL AND METHODS
We performed a retrospective study of all cases of eosinophilic meningitis (EM) admitted to the Territorial Hospital of New Caledonia, from 2004 to 2019. We performed a descriptive and a multivariate analysis to identify association of variables with severe and fatal cases (or cases with sequelae).
CONCLUSION
Angiostrongyliasis was confirmed as being responsible for 17 of the 92 reported EM cases in New Caledonia from 2004 to 2019 with most being young adults and non-walking infants, and with two peaks of incidence one during the dry season and one during the rainy season. Considering the high incidence and regularity of cases, the potential reservoirs should be identified to target prevention campaigns.
引言
嗜酸性粒细胞性脑膜炎是一种罕见的脑膜炎形式，约2%-3%的病例会出现后遗症或死亡。最常见的病原体是广州管圆线虫。本研究的目的是对新喀里多尼亚的病例进行特征描述，并评估广州管圆线虫的感染程度。
材料与方法
我们对2004年至2019年期间新喀里多尼亚地区医院收治的所有嗜酸性粒细胞性脑膜炎（EM）病例进行了回顾性研究。我们进行了描述性和多变量分析，以确定变量与重症和致命病例（或有后遗症的病例）之间的关联。
结论
2004年至2019年期间，新喀里多尼亚报告的92例EM病例中，有17例确诊为管圆线虫病，大多数为年轻成年人和不会走路的婴儿，发病有两个高峰，一个在旱季，一个在雨季。鉴于病例的高发病率和规律性，应确定潜在的储存宿主，以开展预防活动。
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