Lee Jiyeon, Cho Yunjoo, Choi Kyue Hee, Hwang Inwoo, Oh Young Lyun
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Pathol Transl Med. 2021 Sep;55(5):360-365. doi: 10.4132/jptm.2021.06.23. Epub 2021 Aug 13.
Metastatic leiomyosarcoma to the thyroid is an extremely rare occurrence, and only 18 cases have been reported. Here, we report a case of a 37-year-old woman who presented with multiple masses on the scalp. Excisional biopsy was done and the mass revealed fascicles of smooth muscle fibers which showed positive staining for smooth muscle actin, thus confirming the diagnosis of leiomyosarcoma. The patient was also found to have a 0.9 cm mass within the left thyroid. Fine-needle aspiration was done and the cytological smear showed hypercellular spindle cell clusters with hyperchromatic and large nuclei. Normal thyroid follicular cells were found within or around tumor cells. In this report, we present the cytologic findings of metastatic leiomyosarcoma to the thyroid and offer differential diagnoses of the aspirated spindle cells.
甲状腺转移性平滑肌肉瘤极为罕见，仅有18例报道。在此，我们报告一例37岁女性，其头皮出现多个肿物。进行了切除活检，肿物显示为平滑肌纤维束，平滑肌肌动蛋白染色呈阳性，从而确诊为平滑肌肉瘤。该患者左甲状腺内还发现一个0.9厘米的肿物。进行了细针穿刺抽吸，细胞学涂片显示细胞增多的梭形细胞簇，核深染且大。在肿瘤细胞内或其周围发现了正常甲状腺滤泡细胞。在本报告中，我们呈现了甲状腺转移性平滑肌肉瘤的细胞学发现，并对抽吸的梭形细胞进行鉴别诊断。
