2697Scripps Health, Cardiology, San Diego, CA, USA.
540266Scripps Center for Integrative Medicine, La Jolla, CA, USA.
J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X211036875. doi: 10.1177/2515690X211036875.
Worldwide, the turmoil of the SARS-CoV-2 (COVID-19) pandemic has generated a burst of research efforts in search of effective prevention and treatment modalities. Current recommendations on natural supplements arise from mostly anecdotal evidence in other viral infections and expert opinion, and many clinical trials are ongoing. Here the authors review the evidence and rationale for the use of natural supplements for prevention and treatment of COVID-19, including those with potential benefit and those with potential harms. Specifically, the authors review probiotics, dietary patterns, micronutrients, antioxidants, polyphenols, melatonin, and cannabinoids. Authors critically evaluated and summarized the biomedical literature published in peer-reviewed journals, preprint servers, and current guidelines recommended by expert scientific governing bodies. Ongoing and future trials registered on clinicaltrials.gov were also recorded, appraised, and considered in conjunction with the literature findings. In light of the controversial issues surrounding the manufacturing and marketing of natural supplements and limited scientific evidence available, the authors assessed the available data and present this review to equip clinicians with the necessary information regarding the evidence for and potential harms of usage to promote open discussions with patients who are considering dietary supplements to prevent and treat COVID-19.
在全球范围内，SARS-CoV-2（COVID-19）大流行的动荡引发了一波寻找有效预防和治疗方法的研究工作。目前关于天然补品的建议主要来自其他病毒感染的传闻证据和专家意见，许多临床试验正在进行中。在这里，作者回顾了用于预防和治疗 COVID-19 的天然补品的使用证据和原理，包括那些具有潜在益处和潜在危害的补品。具体来说，作者回顾了益生菌、饮食模式、微量营养素、抗氧化剂、多酚、褪黑素和大麻素。作者批判性地评估并总结了在同行评议期刊、预印本服务器以及专家科学管理机构推荐的当前指南上发表的生物医学文献。还记录、评估了在 clinicaltrials.gov 上注册的正在进行和未来的试验，并结合文献结果进行了考虑。鉴于围绕天然补品的制造和营销存在争议问题以及现有科学证据有限，作者评估了可用数据，并提出了本综述，为临床医生提供有关使用证据和潜在危害的必要信息，以促进与考虑使用饮食补充剂预防和治疗 COVID-19 的患者进行开放讨论。
