Department of Orthopaedic Surgery, Qilu Hospital of Shandong University, No.107, Wenhua Xi Road, Jinan, 250012, Shandong, China.
Mol Med. 2021 Aug 12;27(1):86. doi: 10.1186/s10020-021-00350-y.
In recent years, H19, as one of the most well-known long non-coding RNA, has been reported to play important roles in many biological and physiological processes. H19 has been identified to regulate the osteogenic differentiation of various stem cells in many studies. However, the detailed role and regulation mechanism of H19 was not consistent in the reported studies.
In this review article we summarized the effect and mechanism of lncRNA H19 on osteogenic differentiation of various stem cells reported in the published literatures. The role and mechanism of H19, H19 expression changes, effect of H19 on cell proliferation in osteogenic differentiation were respectively reviewed.
An increasing number of studies have provided evidence that H19 play its role in the regulation of stem cell osteogenic differentiation by different mechanisms. Most of the studies favored the positive regulatory effect of H19 through lncRNA-miRNA pathway. The function and underlying mechanisms by which H19 contributes to osteogenic differentiation require further investigation.
近年来，H19 作为最著名的长链非编码 RNA 之一，被报道在许多生物和生理过程中发挥重要作用。许多研究已经确定 H19 可以调节各种干细胞的成骨分化。然而，在报道的研究中，H19 的详细作用和调节机制并不一致。
本文综述了已发表文献中报道的 lncRNA H19 对各种干细胞成骨分化的作用及机制。分别综述了 H19 的作用和机制、H19 表达变化、H19 对成骨分化中细胞增殖的影响。
越来越多的研究提供了证据，表明 H19 通过不同的机制在调节干细胞成骨分化中发挥作用。大多数研究倾向于 H19 通过 lncRNA-miRNA 途径发挥正向调节作用。H19 促进成骨分化的功能和潜在机制需要进一步研究。
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