Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.
School of Stomatology, Shenyang Medical College, Shenyang, China.
Front Immunol. 2021 Jul 27;12:693479. doi: 10.3389/fimmu.2021.693479. eCollection 2021.
Periodontal disease, a common inflammatory disease, is considered a hazardous factor that contributes to the development of diseases of the digestive system as well as other systems. The bridge between periodontitis and systemic diseases is believed to be periodontal pathogens. The intestine, as part of the lower gastrointestinal tract, has a close connection with the oral cavity. Within the intestine, the intestinal barrier acts as a multifunctional system including microbial, mucous, physical and immune barrier. The intestinal barrier forms the body's first line of defense against external pathogens; its breakdown can lead to pathological changes in the gut and other organs or systems. Reports in the literature have described how oral periodontal pathogens and pathobiont-reactive immune cells can transmigrate to the intestinal mucosa, causing the destruction of intestinal barrier homeostasis. Such findings might lead to novel ideas for investigating the relationship between periodontal disease and other systemic diseases. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, which might contribute to understanding the link between periodontitis and gastrointestinal diseases.
牙周病是一种常见的炎症性疾病，被认为是导致消化系统疾病和其他系统疾病发展的危险因素。牙周炎和系统性疾病之间的桥梁被认为是牙周病原体。肠道作为下消化道的一部分，与口腔有密切的联系。在肠道内，肠道屏障作为一个具有微生物、黏液、物理和免疫屏障等多种功能的系统。肠道屏障是人体抵御外来病原体的第一道防线；其破坏可导致肠道和其他器官或系统的病理变化。文献中的报道描述了口腔牙周病原体和与病原体反应的免疫细胞如何迁移到肠道黏膜，导致肠道屏障内稳态的破坏。这些发现可能为研究牙周病与其他系统性疾病之间的关系提供新的思路。本综述总结了牙周病原体对肠道屏障的影响的研究，这可能有助于理解牙周炎与胃肠道疾病之间的联系。
