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肠道微生物群和益生菌在结直肠癌中的作用：发病与进展

Role of Gut Microbiota and Probiotics in Colorectal Cancer: Onset and Progression.

作者信息

Torres-Maravilla Edgar, Boucard Anne-Sophie, Mohseni Amir Hossein, Taghinezhad-S Sedigheh, Cortes-Perez Naima G, Bermúdez-Humarán Luis G

机构信息

Micalis Institute, Université Paris-Saclay, INRAE, AgroParisTech, 78350 Jouy-en-Josas, France.

Department of Microbiology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran.

出版信息

Microorganisms. 2021 May 10;9(5):1021. doi: 10.3390/microorganisms9051021.

DOI:10.3390/microorganisms9051021
PMID:34068653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8151957/
Abstract

The gut microbiota plays an important role in maintaining homeostasis in the human body, and the disruption of these communities can lead to compromised host health and the onset of disease. Current research on probiotics is quite promising and, in particular, these microorganisms have demonstrated their potential for use as adjuvants for the treatment of colorectal cancer. This review addresses the possible applications of probiotics, postbiotics, synbiotics, and next-generation probiotics in colorectal cancer research.

摘要

肠道微生物群在维持人体稳态中发挥着重要作用，这些群落的破坏会导致宿主健康受损和疾病的发生。目前对益生菌的研究很有前景，特别是这些微生物已显示出作为辅助治疗结直肠癌的潜力。本文综述了益生菌、后生元、合生元和下一代益生菌在结直肠癌研究中的可能应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/c82e9ee13ae6/microorganisms-09-01021-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/f6aab61fa239/microorganisms-09-01021-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/5f3bdb045593/microorganisms-09-01021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/429d8c158707/microorganisms-09-01021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/c82e9ee13ae6/microorganisms-09-01021-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/f6aab61fa239/microorganisms-09-01021-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/5f3bdb045593/microorganisms-09-01021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/429d8c158707/microorganisms-09-01021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8694/8151957/c82e9ee13ae6/microorganisms-09-01021-g004.jpg

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Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):480-486. doi: 10.26355/eurrev_202101_24417.
2
Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer.细菌衍生的铁载体抑制散发性结直肠肿瘤和结肠炎相关癌症的肿瘤进展。
Cancer Cell Int. 2021 Jan 6;21(1):21. doi: 10.1186/s12935-020-01723-9.
3
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Biomedicines. 2025 Jun 25;13(7):1554. doi: 10.3390/biomedicines13071554.
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Theabrownin combined with zearalenone suppresses colitis-associated colorectal cancer by inhibiting PI3K/AKT pathway and enhancing microbial propionate production.茶褐素与玉米赤霉烯酮联合通过抑制PI3K/AKT通路和增强微生物丙酸生成来抑制结肠炎相关的结直肠癌。
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