2例肾移植受者感染人腺病毒11型：疑似供体源性感染。
Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection.
作者信息
Sherman Amy C, Lu Xiaoyan, Schneider Eileen, Langston Amelia, Ellis Carla L, Pastan Stephen, Bhatnagar Julu, Reagan-Steiner Sarah, Annambhotla Pallavi, Lindstrom Stephen, Mehta Aneesh, Pouch Stephanie M, Sexton Marybeth E
机构信息
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Open Forum Infect Dis. 2021 Feb 25;8(3):ofab092. doi: 10.1093/ofid/ofab092. eCollection 2021 Mar.
BACKGROUND
Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection.
METHODS
Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed.
RESULTS
WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir.
CONCLUSIONS
Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.
背景
人类腺病毒（HAdV）感染可导致实体器官移植（SOT）受者的高死亡率，关于供体来源感染的报道罕见。
方法
描述了两名接受来自同一供体肾脏的HAdV - 11感染的肾移植受者。进行了全基因组测序（WGS）。
结果
WGS显示这2株HAdV - 11分离株的核苷酸序列同一性为100%。患者表现出不同的临床综合征，且均接受了布林西多福韦治疗。
结论
推测供体来源的HAdV感染率较低；然而，SOT受者中播散性HAdV感染可能很严重，临床医生应了解其临床病程和治疗选择。
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