Bambery P, Sakhuja V, Gupta A, Behera D, Kaur U, Bhusnurmath S R, Jindal S K, Malik S K, Deodhar S D, Chugh K S
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Rheumatol Int. 1987;7(6):243-7. doi: 10.1007/BF00270523.
Eleven patients with Wegener's granulomatosis were seen at this Institute over a period of 20 years. There were six men and five women. The average age of presentation was 38.3 years, and the mean duration of symptoms was 10.5 months. Constitutional symptoms (82%), cough (82%), ocular symptoms (64%), arthralgias (55%), rhinorrhoea (55%), haemoptysis (45%), nasal granuloma (45%), otorrhoea (36%), sinusitis (36%), skin lesions (27%), and renal failure (27%) were the clinical manifestations encountered. All patients had an elevated ESR, and 55% had leucocytosis. Proteinuria and haematuria were observed in 64% and 55% respectively. Chest radiographs were abnormal in 82%. In four patients the disease had a fulminant course and the patients died before adequate treatment was given. Two patients received corticosteroids alone and have since been lost to follow up. Five (45%) received adequate cytotoxic therapy and have done well for 8-46 months (mean, 24.8 months) after diagnosis. Wegener's granulomatosis in India is apparently similar to that seen elsewhere, but the high incidence of tuberculosis interferes with early diagnosis and treatment.
在20年的时间里，该研究所共接诊了11例韦格纳肉芽肿患者。其中男性6例，女性5例。就诊时的平均年龄为38.3岁，症状的平均持续时间为10.5个月。临床表现包括全身症状（82%）、咳嗽（82%）、眼部症状（64%）、关节痛（55%）、流涕（55%）、咯血（45%）、鼻肉芽肿（45%）、耳漏（36%）、鼻窦炎（36%）、皮肤病变（27%）和肾衰竭（27%）。所有患者的血沉均升高，55%的患者有白细胞增多。分别有64%和55%的患者观察到蛋白尿和血尿。82%的胸部X光片异常。4例患者病情呈暴发性，在给予充分治疗前死亡。2例患者仅接受了皮质类固醇治疗，此后失去随访。5例（45%）接受了充分的细胞毒性治疗，诊断后8 - 46个月（平均24.8个月）情况良好。印度的韦格纳肉芽肿显然与其他地方所见相似，但结核病的高发病率干扰了早期诊断和治疗。
