Watkins Angela S, Kempen John H, Choi Dongseok, Liesegang Teresa L, Pujari S S, Newcomb Craig, Nussenblatt Robert B, Rosenbaum James T, Thorne Jennifer E, Foster C Stephen, Jabs Douglas A, Levy-Clarke Grace A, Suhler Eric B, Smith Justine R
J Ocul Biol Dis Infor. 2009 Dec 12;3(1):12-19. doi: 10.1007/s12177-009-9044-4.
Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcerative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease.
抗中性粒细胞胞浆抗体（ANCA）阳性血管炎——该术语最近用于韦格纳肉芽肿——是一种罕见的多系统炎症，其特征为坏死性肉芽肿和血管炎。我们在美国五家炎症性眼病诊所抽取的一组患者中调查了这种疾病的眼部表现。在8562例眼部炎症患者中，59例被诊断为ANCA阳性血管炎；本研究纳入了35名男性和21名女性，年龄在16至96岁之间。眼部诊断为巩膜炎（75.0%）、葡萄膜炎（17.9%）以及其他眼部炎症性疾病（33.9%），包括周边溃疡性角膜炎和眼眶假瘤。眼部疾病的平均病程为4.6年。分别有85.7%和78.5%的患者使用了口服糖皮质激素和其他全身免疫抑制剂。随着时间推移，ANCA阳性血管炎患者的死亡率比其他炎症性眼病患者高2.75倍。
