Patel Dinesh Kumar
Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences Naini, Prayagraj, 211007, Uttar Pradesh, India.
Cardiovasc Hematol Disord Drug Targets. 2021;21(2):104-114. doi: 10.2174/1871529X21666210812111931.
Herbal drugs and their derived phytochemicals are valuable for human beings as a source of a vital component of food material and drugs. Flavonoids are naturally occurring phytochemicals produced in plants through metabolisms, and they have anti-hyperlipidemia, anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in fruits, nuts, vegetables, seeds, stems, flowers, and tea. Kaempferol is a natural flavonoidal compound present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis, and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L., Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, proapoptotic, cardio-protective and anti-cancer activities.
Glycosides of kaempferol such as kaempferitrin, also called kaempferol 3,7-dirhamnoside are known to be more abundant than their flavonoid monomers in plants. Various literature databases have been searched to collect all the scientific information of kaempferitrin in the present investigation and analyzed in order to know the therapeutic benefit and biological potential of kaempferitrin. Moreover, all the information has been presented here in two broad sections, i.e., pharmacological and analytical.
From the analysis of all the collected and presented information, it was found that kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes and related complications. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant, anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory, and natriuretic properties and inhibits cell proliferation and apoptosis. Kaempferitrin also improves the meat quality of broiler chickens.
The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.
草药及其衍生的植物化学物质作为食物原料和药物的重要组成部分来源，对人类具有重要价值。黄酮类化合物是植物通过新陈代谢产生的天然植物化学物质，具有抗高血脂、抗炎、抗氧化和抗凋亡活性。在水果、坚果、蔬菜、种子、茎、花和茶中都已鉴定出黄酮类化合物。山奈酚是一种天然黄酮类化合物，存在于苹果、西兰花、草莓、豆类、葡萄柚、蜂胶等可食用植物以及芦荟、银杏、迷迭香、藏红花、贯叶连翘等药用植物中。山奈酚具有抗氧化、抗炎、抗凋亡、促凋亡、心脏保护和抗癌活性。
已知山奈酚苷，如也称为山奈酚3,7 - 二鼠李糖苷的山奈素，在植物中比其黄酮类单体更为丰富。在本次研究中，检索了各种文献数据库以收集山奈素的所有科学信息并进行分析，以便了解山奈素的治疗益处和生物学潜力。此外，所有信息在此分为两个主要部分呈现，即药理学和分析学。
通过对所有收集和呈现的信息进行分析，发现山奈素具有强大的胰岛素模拟潜力，可用于治疗糖尿病及相关并发症。然而，它还表现出抗氧化、抗炎、抗惊厥、抗骨质疏松、抗抑郁、驱虫、免疫刺激和利钠特性，并抑制细胞增殖和凋亡。山奈素还能改善肉鸡的肉质。
本研究中呈现的信息对于证明山奈素在科学领域的生物学重要性和治疗潜力具有重要价值。
