Cardiovascular Surgery Discipline, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Affiliated Hospitals of Associação Paulista para o Desenvolvimento da Medicina (SPDM), São Paulo, São Paulo, Brazil.
Braz J Cardiovasc Surg. 2021 Jun 1;36(3):397-405. doi: 10.21470/1678-9741-2020-0451.
Coronary artery bypass grafting (CABG) has consolidated its role as the most effective procedure for treating patients with advanced atherosclerotic coronary artery disease, reducing the long-term risk of myocardial infarction and death compared to other therapies and relieving angina. Despite the recognized benefits afforded by surgical myocardial revascularization, a subset of higher-risk patients bears a more elevated risk of perioperative stroke. Stroke remains the drawback of conventional CABG and has been strongly linked to aortic manipulation (cannulation, cross-clamping, and side-biting clamping for the performance of proximal aortic anastomoses) and the use of cardiopulmonary bypass. Adoption of off-pump CABG (OPCAB) is demonstrated to lower the risk of perioperative stroke, as well as reducing the risk of short-term mortality, renal failure, atrial fibrillation, bleeding, and length of intensive care unit stay. However, increased risk persists owing to the need for the tangential ascending aorta clamping to construct the proximal anastomosis. The concept of anaortic (aorta no-touch) OPCAB (anOPCAB) stems from eliminating ascending aorta manipulation, virtually abolishing the risk of embolism caused by aortic wall debris into the brain circulation. The adoption of anOPCAB has been shown to further decrease the risk of postoperative stroke, especially in higher-risk patients, entailing a step forward and a refinement of outcomes provided by the primeval OPCAB technique. Therefore, anOPCAB has been the recommended technique in patients with cerebrovascular disease and/or calcification or atheromatous plaque in the ascending aorta and should be preferred in patients with high-risk factors for neurological damage and stroke.
冠状动脉旁路移植术(CABG)已巩固其作为治疗晚期动脉粥样硬化性冠状动脉疾病患者的最有效方法的地位,与其他治疗方法相比,可降低心肌梗死和死亡的长期风险,并缓解心绞痛。尽管手术心肌血运重建带来了公认的益处,但一部分高风险患者的围手术期卒中风险更高。卒中仍然是传统 CABG 的缺点,并与主动脉操作(插管、交叉钳夹和侧咬钳夹以进行近端主动脉吻合)和体外循环的使用密切相关。采用非体外循环冠状动脉旁路移植术(OPCAB)已被证明可降低围手术期卒中风险,并降低短期死亡率、肾衰竭、心房颤动、出血和重症监护病房住院时间的风险。然而,由于需要切线升主动脉夹闭来构建近端吻合,风险仍然增加。无升主动脉(主动脉不接触)OPCAB(anOPCAB)的概念源于消除升主动脉操作,实际上消除了主动脉壁碎片进入脑循环引起的栓塞风险。采用 anOPCAB 已被证明可进一步降低术后卒中风险,尤其是在高风险患者中,这是对原始 OPCAB 技术提供的结果的进一步改进。因此,anOPCAB 已被推荐用于有脑血管疾病和/或升主动脉钙化或粥样斑块的患者,并且应优先考虑有神经损伤和卒中高风险因素的患者。