Institute for Food, Nutrition and Health, University of Reading, Reading, United Kingdom.
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Adv Nutr. 2019 Nov 1;10(6):1066-1075. doi: 10.1093/advances/nmz050.
The prevalence of type 2 diabetes (T2D) has increased rapidly. Adopting a heathy diet is suggested as one of the effective behaviors to prevent or delay onset of T2D. Dairy consumption has been recommended as part of a healthy diet, but there remains uncertainty in both the scientific community and the public about the effect of different dairy products on T2D risk. In a recent workshop, the evidence on dairy products and T2D risk was presented and discussed by a group of experts. The main conclusions from the workshop are presented in this position paper and are as follows. 1) Available evidence from large prospective cohort studies and limited randomized controlled trials (RCTs) suggests that total dairy consumption has a neutral or moderately beneficial effect on T2D risk. 2) Increasing evidence from prospective cohort studies indicates that yogurt is most strongly associated with a lower T2D risk, but evidence from RCTs is scarce. 3) Fatty acids from dairy (medium-chain, odd, and very long-chain SFAs as well as trans-palmitoleic acid) are associated with lower T2D risk and improved metabolic health, but more research is needed on studies that explore cause and effect relations to exclude the possibility that the dairy fatty acids simply serve as markers of overall dairy consumption. 4) The food matrix can be a stronger determinant of health effects than SFA content. This review further identifies research gaps in the existing knowledge and highlights key research questions that need to be addressed to better understand the impact of dairy consumption on future T2D risk.
2 型糖尿病(T2D)的患病率迅速增加。采用健康饮食被认为是预防或延迟 T2D 发病的有效行为之一。乳制品消费已被推荐为健康饮食的一部分,但科学界和公众对不同乳制品对 T2D 风险的影响仍存在不确定性。在最近的一次研讨会上,一组专家介绍和讨论了乳制品与 T2D 风险的证据。本立场文件提出了研讨会的主要结论如下。1)来自大型前瞻性队列研究和有限的随机对照试验(RCT)的证据表明,总乳制品消费对 T2D 风险具有中性或适度有益的影响。2)来自前瞻性队列研究的越来越多的证据表明,酸奶与较低的 T2D 风险相关性最强,但 RCT 的证据很少。3)来自乳制品的脂肪酸(中链、奇数和超长链 SFAs 以及反式棕榈油酸)与较低的 T2D 风险和改善的代谢健康相关,但需要更多研究来探索因果关系,以排除乳制品脂肪酸只是整体乳制品消费的标志物的可能性。4)食品基质可能比 SFA 含量更能决定健康效应。本综述进一步确定了现有知识中的研究空白,并强调了需要解决的关键研究问题,以更好地了解乳制品消费对未来 T2D 风险的影响。