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一项文化体育活动干预措施对降低夏威夷原住民高血压患者血压的成本效益分析

Cost Effectiveness of a Cultural Physical Activity Intervention to Reduce Blood Pressure Among Native Hawaiians with Hypertension.

作者信息

Railey Ashley F, Muller Clemma, Noonan Carolyn, Schmitter-Edgecombe Maureen, Sinclair Ka'imi, Kim Corin, Look Mele, Kaholokula J Keawe'aimoku

机构信息

Institute for Research and Education to Advance Community Health (IREACH), Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.

Department of Sociology, Indiana University, 1022 E. Third St, Bloomington, IN, 47405-7103, USA.

出版信息

Pharmacoecon Open. 2022 Jan;6(1):85-94. doi: 10.1007/s41669-021-00291-6. Epub 2021 Aug 13.

Abstract

OBJECTIVE

The aim of this study was to calculate the costs and assess whether a culturally grounded physical activity intervention offered through community-based organizations is cost effective in reducing blood pressure among Native Hawaiian adults with hypertension.

METHODS

Six community-based organizations in Hawai'i completed a randomized controlled trial between 2015 and 2019. Overall, 263 Native Hawaiian adults with uncontrolled hypertension (≥ 140 mmHg systolic, ≥ 90 mmHg diastolic) were randomized to either a 12-month intervention group of hula (traditional Hawaiian dance) lessons and self-regulation classes, or to an education-only waitlist control group. The primary outcome was change in systolic blood pressure collected at baseline and 3, 6, and 12 months for the intervention compared with the control group. Incremental cost-effectiveness ratios (ICERs) were calculated for primary and secondary outcomes. Non-parametric bootstrapping and sensitivity analyses evaluated uncertainty in parameters and outcomes.

RESULTS

The mean intervention cost was US$361/person, and the 6-month ICER was US$103/mmHg reduction in systolic blood pressure and US$95/mmHg in diastolic blood pressure. At 12 months, the intervention group maintained reductions in blood pressure, which exceeded reductions for usual care based on blood pressure outcomes. The change in blood pressure at 12 months resulted in ICERs of US$100/mmHg reduction in systolic blood pressure and US$93/mmHg in diastolic blood pressure. Sensitivity analyses suggested that at the estimated intervention cost, the probability that the program would lower systolic blood pressure by 5 mmHg was 67 and 2.5% at 6 and 12 months, respectively.

CONCLUSION

The 6-month Ola Hou program may be cost effective for low-resource community-based organizations. Maintenance of blood pressure reductions at 6 and 12 months in the intervention group contributed to potential cost effectiveness. Future studies should further evaluate the cost effectiveness of indigenous physical activity programs in similar settings and by modeling lifetime costs and quality-adjusted life-years.

TRIAL REGISTRATION NUMBER

NCT02620709.

摘要

目的

本研究旨在计算成本,并评估通过社区组织提供的基于文化的体育活动干预措施在降低患有高血压的夏威夷原住民成年人血压方面是否具有成本效益。

方法

夏威夷的六个社区组织在2015年至2019年期间完成了一项随机对照试验。总体而言,263名患有未控制高血压(收缩压≥140 mmHg,舒张压≥90 mmHg)的夏威夷原住民成年人被随机分为为期12个月的草裙舞(传统夏威夷舞蹈)课程和自我调节课程干预组,或仅接受教育的等待名单对照组。主要结局是干预组与对照组相比,在基线以及3、6和12个月时收集的收缩压变化。计算主要和次要结局的增量成本效益比(ICER)。非参数自举法和敏感性分析评估了参数和结局的不确定性。

结果

平均干预成本为每人361美元,6个月时的ICER为收缩压每降低1 mmHg 103美元,舒张压每降低1 mmHg 95美元。在12个月时,干预组的血压持续降低,基于血压结局,其降低幅度超过了常规护理。12个月时的血压变化导致收缩压每降低1 mmHg的ICER为100美元,舒张压每降低1 mmHg的ICER为93美元。敏感性分析表明,在估计的干预成本下,该项目在6个月和12个月时使收缩压降低5 mmHg的概率分别为67%和2.5%。

结论

为期6个月的奥拉·侯项目对于资源匮乏的社区组织可能具有成本效益。干预组在6个月和12个月时维持血压降低有助于潜在的成本效益。未来的研究应进一步评估类似环境下本土体育活动项目的成本效益,并通过模拟终身成本和质量调整生命年进行评估。

试验注册号

NCT02620709。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbae/8807791/e527b622b5b2/41669_2021_291_Fig1_HTML.jpg

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