Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150, Seongan-ro, Gangdong-gu, Seoul, 05355, South Korea.
Graefes Arch Clin Exp Ophthalmol. 2022 Jan;260(1):235-246. doi: 10.1007/s00417-021-05341-7. Epub 2021 Aug 14.
The purpose of this study was to assess the diagnostic ability of the new area-based parameter retinal nerve fiber layer to disc ratio (RDR) for discriminating between glaucoma and non-glaucomatous retinal nerve fiber layer defects (RNFLDs).
This retrospective cross-sectional study included 42 branch retinal vein occlusion (BRVO) eyes with RNFLD, 42 open-angle glaucoma (OAG) eyes, and 42 healthy control eyes that were matched with optic disc size. The RDR, peripapillary retinal nerve fiber layer thickness (pRNFLT), Bruch's membrane opening-minimum rim width (BMO-MRW), and Bruch's membrane opening-minimum rim area (BMO-MRA) were analyzed. The areas under the receiver operating characteristic curves (AUCs) were calculated for each parameter.
The OAG and BRVO groups had similar global pRNFLT (87.57 ± 7.07 µm and 89.71 ± 12.21 µm, respectively), but these were thinner than those of the healthy group (102.71 ± 8.95 µm, p < 0.001 and p < 0.001, respectively). RDR was lowest in the BRVO group (0.755 ± 0.121, p < 0.001) and highest in the OAG group (1.111 ± 0.145, p < 0.001). Global BMO-MRW was significantly lower in the OAG group (194.36 ± 23.09 µm) than in the BRVO (269.69 ± 42.77 µm, p < 0.001) and healthy (273.48 ± 30.92 µm, p < 0.001) groups. Total BMO-MRA of the OAG group (0.88 ± 0.12 mm) was significantly lower than that of the BRVO (1.32 ± 0.19 mm, p < 0.001) and healthy (1.30 ± 0.21 mm, p < 0.001) groups. AUC for discriminating between the OAG and BRVO was 0.986 for total BMO-MRA and 0.970 for RDR (p = 0.192).
In clinical practice, RDR may perform well as a parameter to distinguish between glaucoma and non-glaucomatous RNFLD.
本研究旨在评估新的基于区域的参数视网膜神经纤维层与视盘比（RDR）在鉴别青光眼和非青光眼性视网膜神经纤维层缺损（RNFLD）方面的诊断能力。
本回顾性横断面研究纳入了 42 只伴有 RNFLD 的分支视网膜静脉阻塞（BRVO）眼、42 只开角型青光眼（OAG）眼和 42 只与视盘大小相匹配的健康对照组眼。分析了 RDR、视盘周围视网膜神经纤维层厚度（pRNFLT）、Bruch 膜开口最小 rim 宽度（BMO-MRW）和 Bruch 膜开口最小 rim 面积（BMO-MRA）。计算了每个参数的受试者工作特征曲线下面积（AUCs）。
OAG 组和 BRVO 组的全局 pRNFLT 相似（分别为 87.57±7.07 µm 和 89.71±12.21 µm），但均低于健康对照组（分别为 102.71±8.95 µm，p<0.001 和 p<0.001）。RDR 在 BRVO 组最低（0.755±0.121，p<0.001），在 OAG 组最高（1.111±0.145，p<0.001）。OAG 组的全局 BMO-MRW 明显低于 BRVO 组（269.69±42.77 µm，p<0.001）和健康对照组（273.48±30.92 µm，p<0.001）。OAG 组的总 BMO-MRA（0.88±0.12 mm）明显低于 BRVO 组（1.32±0.19 mm，p<0.001）和健康对照组（1.30±0.21 mm，p<0.001）。用于区分 OAG 和 BRVO 的 AUC 为总 BMO-MRA 的 0.986 和 RDR 的 0.970（p=0.192）。
在临床实践中，RDR 可能是一种很好的参数，可用于区分青光眼和非青光眼性 RNFLD。
