Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Adv Drug Deliv Rev. 2021 Nov;178:113921. doi: 10.1016/j.addr.2021.113921. Epub 2021 Aug 11.
The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release.
目前的口服固体制剂制造解决方案从根本上基于 19 世纪的技术。这种方法非常适合大规模生产一刀切的产品；然而，它不允许直接对药物成品进行个性化和大规模定制。为了为患者提供更好的治疗方法，对创新制造概念和产品设计原则的需求不断增加。增材制造为药物产品的分隔提供了可能性，包括设计空间分离的多药物和功能性赋形剂隔室。这种分隔的解决方案可以进一步扩展到模块化设计思维。模块化设计是指将含有一定量药物化合物和相关功能赋形剂的构建块组合成更大的最终产品。通过设计可以根据每个患者的个体需求制造的分隔和反应性产品结构，实施模块化设计原则为在健康科学中实现新兴的个性化潜力铺平了道路。本文将介绍现有的分隔产品设计原则，并讨论将这些原则集成到可食用电子产品中，以实现药物释放的创新控制。
