玉竹中的细胞毒性甾体糖苷。
Cytotoxic steroidal glycosides from Polygonatum odoratum (Mill.) Druce.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
出版信息
Phytochemistry. 2021 Nov;191:112906. doi: 10.1016/j.phytochem.2021.112906. Epub 2021 Aug 12.
Twenty-five steroidal glycosides including eight undescribed compounds which were named as polygonatumosides H-O, were isolated from the 70 % EtOH extract of rhizomes of Polygonatum odoratum (Mill.) Druce (Asparagaceae). Their structures were elucidated by extensive spectroscopic analyses and chemical methods. The isolated compounds were evaluated cytotoxicity against three human cancer cell lines: human non-small cell lung cancer (A549), human epithelial colorectal adenocarcinoma (Caco2), and human hepatocellular carcinoma (HepG2) cells. Five compounds showed cytotoxicity against these cell lines with IC values in the range of 1.7-30.8 μM.
从百合科黄精属植物玉竹（Polygonatum odoratum (Mill.) Druce）的 70%乙醇提取物中分离得到 25 个甾体糖苷，包括 8 个未见文献报道的化合物，命名为玉竹皂苷 H-O。通过广泛的光谱分析和化学方法阐明了它们的结构。对分离得到的化合物进行了体外细胞毒活性测试，选用三种人源肿瘤细胞株：人非小细胞肺癌（A549）、人结肠癌细胞（Caco2）和人肝癌细胞（HepG2）进行测试，其中 5 个化合物对这 3 种肿瘤细胞株均具有细胞毒性，IC 值范围为 1.7-30.8μM。
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