[某种物质]的甲醇提取物通过改善肠道短链脂肪酸和气体生成来调节小鼠肠道微生物群失调，从而改善结肠炎。

The Methanol Extract of Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice.

作者信息

Ye Xuewei, Pi Xionge, Zheng Wenxin, Cen Yingxin, Ni Jiahui, Xu Langyu, Wu Kefei, Liu Wei, Li Lanjuan

机构信息

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.

Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Department of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.

出版信息

Front Nutr. 2022 May 12;9:899421. doi: 10.3389/fnut.2022.899421. eCollection 2022.

The potential impacts of methanol extract from on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of HS-related bacteria (e.g., ) and the lower level of HS and higher contents of SCFA-related bacteria (e.g., ). Taken together, the effects of methanol extract from are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis.

本研究使用葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠，评估了[YZM指代不明，可能是某种物质]甲醇提取物对结肠组织病理学、肠道气体产生、短链脂肪酸（SCFAs）和肠道微生物群组成的潜在影响。这些结果表明，YZM增加了DSS诱导的结肠炎小鼠的结肠长度，并改善了结肠组织病理学。此外，给予YZM可逆转肠道微生物群组成，导致与硫化氢（HS）相关细菌（例如[此处细菌名称缺失]）受到抑制，HS水平降低，与SCFA相关细菌（例如[此处细菌名称缺失]）含量升高。综上所述，对[YZM指代不明，可能是某种物质]甲醇提取物的作用进行研究，为其作为功能性食品和临床药物的应用提供新的启示和线索。我们的研究首次揭示了溃疡性结肠炎中肠道气体产生与关键细菌之间的关系。