Hubei Province Hospital of Traditional Chinese Medicine, Wuhan, China.
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Front Immunol. 2021 Jul 28;12:701295. doi: 10.3389/fimmu.2021.701295. eCollection 2021.
The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.
目前由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）疫情已成为人类的全球性威胁。感染 SARS-CoV-2 可导致广泛的临床表现。有报道称 COVID-19 与眼部异常有关，但未具体说明损害的性质。在这里，我们报告了一例女性患者的病例，该患者在 COVID-19 康复后出院两个月因眼部并发症再次住院被诊断为青光眼。同时，在上呼吸道中发现该患者 SARS-CoV-2 再次呈阳性。通过针对 SARS-CoV-2 的 N 蛋白和 S 蛋白的抗体进行免疫染色，在房水中也诊断出了感染。鉴于眼睛是免疫特惠部位，我们推测 SARS-CoV-2 在眼睛中存活下来，导致患者 SARS-CoV-2 再次检测呈阳性。
