Emerg Infect Dis. 2021 Oct;27(10):2578-2587. doi: 10.3201/eid2710.210061. Epub 2021 Aug 16.
The serial interval and effective reproduction number for coronavirus disease (COVID-19) are heterogenous, varying by demographic characteristics, region, and period. During February 1-July 13, 2020, we identified 4,080 transmission pairs in Georgia, USA, by using contact tracing information from COVID-19 cases reported to the Georgia Department of Public Health. We examined how various transmission characteristics were affected by symptoms, demographics, and period (during shelter-in-place and after subsequent reopening) and estimated the time course of reproduction numbers for all 159 Georgia counties. Transmission varied by time and place but also by persons' sex and race. The mean serial interval decreased from 5.97 days in February-April to 4.40 days in June-July. Younger adults (20-50 years of age) were involved in most transmission events occurring during or after reopening. The shelter-in-place period was not long enough to prevent sustained virus transmission in densely populated urban areas connected by major transportation links.
新型冠状病毒疾病(COVID-19)的连续间隔和有效繁殖数是异构的,因人口统计学特征、地区和时期而异。2020 年 2 月 1 日至 7 月 13 日,我们通过从向佐治亚州公共卫生部报告的 COVID-19 病例中获取的接触追踪信息,在美国佐治亚州确定了 4080 对传播对。我们研究了各种传播特征如何受到症状、人口统计学和时期(在就地避难所期间和随后重新开放后)的影响,并估计了佐治亚州所有 159 个县的繁殖数的时间过程。传播因时间和地点而异,但也因个人的性别和种族而异。平均连续间隔从 2 月至 4 月的 5.97 天减少到 6 月至 7 月的 4.40 天。年轻人(20-50 岁)参与了大多数在重新开放期间或之后发生的传播事件。就地避难所的时间不够长,无法阻止人口稠密的城市地区之间通过主要交通枢纽进行持续的病毒传播。