State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
Biomaterials. 2021 Sep;276:121057. doi: 10.1016/j.biomaterials.2021.121057. Epub 2021 Aug 9.
Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.
术后残留肿瘤细胞是癌症复发和进展的主要原因，但令人遗憾的是，治疗选择有限。在这项工作中，在温敏水凝胶[（聚-DL-丙交酯）-（聚乙二醇）-（聚-DL-丙交酯），PLEL]上借助放电等离子体产生可填充的等离子体激活生物凝胶，用于癌症的局部术后治疗。体内数据表明，等离子体激活的 PLEL 生物凝胶（PAPB）可消除手术后切除的残余肿瘤组织，还可抑制原位复发，同时无明显的全身毒性。此外，PAPB 具有优异的储存能力，允许缓慢释放等离子体产生的活性氧（ROS），并在体外表现出良好的 ROS 介导的抗癌作用。我们的结果表明，新型等离子体激活生物凝胶是癌症局部术后治疗的有效治疗剂。
