Li Xinlin, Xu Xinyi, Xu Mengfei, Geng Zhaoli, Ji Ping, Liu Yi
Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.
Front Bioeng Biotechnol. 2023 Feb 16;11:1140436. doi: 10.3389/fbioe.2023.1140436. eCollection 2023.
When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.
当具有优异生物相容性和生物降解性的水凝胶材料作为治疗癌症的新型优良药物载体时,它们具有以下三个优点。首先,水凝胶材料可用作精确的控释系统,能够连续且顺序地释放化疗药物、放射性核素、免疫抑制剂、热疗剂、光疗剂等物质,并广泛应用于通过放疗、化疗、免疫疗法、热疗、光动力疗法和光热疗法治疗癌症。其次,水凝胶材料具有多种尺寸和多种给药途径,可靶向不同位置和类型的癌症。这大大提高了药物的靶向性,从而降低药物剂量并提高治疗效果。最后,水凝胶可根据内部和外部环境刺激智能响应环境变化,以便抗癌活性物质能够按需远程控制释放。结合上述优点,水凝胶材料已成为癌症治疗领域的热门,为进一步提高癌症患者的生存率和生活质量带来了希望。