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一名哮喘控制不佳的患者出现无创伤性前臂肿胀。

Atraumatic forearm swelling in a patient with poorly controlled asthma.

作者信息

Leon Matthew, Liotta Robert, Aryal Shambhu, Vangeertruyden Peter, Tintle Scott, Klassen-Fischer Mary, Holley Aaron, Kelly William, Collen Jacob

机构信息

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Thoracic Radiology, Uniformed Services of the Health Sciences, Bethesda, MD, USA.

出版信息

Respir Med Case Rep. 2021 Jul 1;33:101454. doi: 10.1016/j.rmcr.2021.101454. eCollection 2021.

DOI:10.1016/j.rmcr.2021.101454
PMID:34401293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8349057/
Abstract

We present a case of sarcoidosis presenting as unilateral forearm swelling. A 65-year-old male with a long history of asthma presented with unexplained left forearm and hand swelling. Over many years, chest imaging had been devoid of adenopathy or parenchymal findings suspicious for sarcoid, until after the extremity findings emerged. The patient was diagnosed based on subcutaneous, dermal and mediastinal lymph node histopathology. Sarcoid presenting with isolated extremity findings prior to more typical pulmonary manifestations is rare even for cutaneous or soft tissue sarcoid, highlighting the need to maintain a high index of suspicion for sarcoidosis.

摘要

我们报告一例以单侧前臂肿胀为表现的结节病病例。一名有长期哮喘病史的65岁男性出现不明原因的左前臂和手部肿胀。多年来,胸部影像学检查未发现淋巴结肿大或提示结节病的实质病变,直到出现肢体病变后才发现。该患者根据皮下、真皮和纵隔淋巴结组织病理学检查确诊。结节病在出现更典型的肺部表现之前先出现孤立的肢体病变,即使对于皮肤或软组织结节病来说也很罕见,这凸显了对结节病保持高度怀疑指数的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/85df6ed8d100/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/29a5662beeb8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/7c3f97eb5795/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/3779beb2d234/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/fdfbd817b31a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/85df6ed8d100/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/29a5662beeb8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/7c3f97eb5795/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/3779beb2d234/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/fdfbd817b31a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/795e/8349057/85df6ed8d100/gr5.jpg

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本文引用的文献

1
Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.结节病的诊断与检测:美国胸科学会临床实践指南
Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51. doi: 10.1164/rccm.202002-0251ST.
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Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis.德尔福共识建议在肺结节病的治疗算法。
Eur Respir Rev. 2020 Mar 20;29(155). doi: 10.1183/16000617.0146-2019. Print 2020 Mar 31.
3
Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature.
上下肢皮下结节病:一例报告并文献复习
World J Clin Cases. 2019 Sep 6;7(17):2505-2512. doi: 10.12998/wjcc.v7.i17.2505.
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Familial aggregation and heritability of sarcoidosis: a Swedish nested case-control study.家族聚集性和结节病的遗传性:一项瑞典巢式病例对照研究。
Eur Respir J. 2018 Aug 16;52(2). doi: 10.1183/13993003.00385-2018. Print 2018 Aug.
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Treatment of sarcoidosis: grading the evidence.结节病的治疗:证据分级。
Expert Rev Clin Pharmacol. 2018 Jul;11(7):677-687. doi: 10.1080/17512433.2018.1486706. Epub 2018 Jun 18.
6
Management of extrapulmonary sarcoidosis: challenges and solutions.肺外结节病的管理:挑战与解决方案
Ther Clin Risk Manag. 2016 Nov 7;12:1623-1634. doi: 10.2147/TCRM.S74476. eCollection 2016.
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Eur Respir J. 2013 Apr;41(4):778-80. doi: 10.1183/09031936.00159912.
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9
Obstructive lung function in sarcoidosis may be missed, especially in older white patients.结节病患者的阻塞性肺功能可能被漏诊,尤其是老年白人患者。
Eur Respir J. 2012 Mar;39(3):775-7. doi: 10.1183/09031936.00103811.
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Subcutaneous sarcoidosis.皮下结节病
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