Zhang Mei-Ling, Sun Yan-Ping, Liu Yan, Pan Juan, Guan Wei, Li Xiao-Mao, Wang Si-Yi, Naseem Anam, Yang Bing-You, Kuang Hai-Xue
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, People's Republic of China.
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, People's Republic of China.
Fitoterapia. 2021 Mar;149:104827. doi: 10.1016/j.fitote.2021.104827. Epub 2021 Jan 8.
Five new sesquiterpenoids named acasenterpene A-E (1-5) were isolated from the fruits of Acanthopanax senticosus. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HR-ESI-MS) combined with physico-chemical analysis methods (enzyme hydrolysis, optical rotation, and CD). The cytotoxicity of all compounds in vitro against four human cancer cell lines (MGC-803, Ishikawa, LN-229 and SMMC-7721) were evaluated by CCK-8 assay.
从刺五加果实中分离出5个新的倍半萜类化合物，命名为刺五加萜A - E（1 - 5）。通过广泛的光谱数据分析（一维、二维核磁共振和高分辨电喷雾电离质谱）并结合物理化学分析方法（酶水解、旋光度和圆二色光谱）确定了所有化合物的结构。采用CCK - 8法评估了所有化合物对4种人癌细胞系（MGC - 803、Ishikawa、LN - 229和SMMC - 7721）的体外细胞毒性。
